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      Assessing Inhalation Exposures Associated with Contamination Events in Water Distribution Systems

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      PLoS ONE
      Public Library of Science

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          Abstract

          When a water distribution system (WDS) is contaminated, short-term inhalation exposures to airborne contaminants could occur as the result of domestic water use. The most important domestic sources of such exposures are likely to be showering and the use of aerosol-producing humidifiers, i.e., ultrasonic and impeller (cool-mist) units. A framework is presented for assessing the potential effects of short-term, system-wide inhalation exposures that could result from such activities during a contamination event. This framework utilizes available statistical models for showering frequency and duration, available exposure models for showering and humidifier use, and experimental results on both aerosol generation and the volatilization of chemicals during showering. New models for the times when showering occurs are developed using time-use data for the United States. Given a lack of similar models for how humidifiers are used, or the information needed to develop them, an analysis of the sensitivity of results to assumptions concerning humidifier use is presented. The framework is applied using network models for three actual WDSs. Simple models are developed for estimating upper bounds on the potential effects of system-wide inhalation exposures associated with showering and humidifier use. From a system-wide, population perspective, showering could result in significant inhalation doses of volatile chemical contaminants, and humidifier use could result in significant inhalation doses of microbial contaminants during a contamination event. From a system-wide perspective, showering is unlikely to be associated with significant doses of microbial contaminants. Given the potential importance of humidifiers as a source of airborne contaminants during a contamination event, an improved understanding of the nature of humidifier use is warranted.

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          Most cited references28

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          A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry.

          Biopolyesters polyhydroxyalkanoates (PHA) produced by many bacteria have been investigated by microbiologists, molecular biologists, biochemists, chemical engineers, chemists, polymer experts and medical researchers. PHA applications as bioplastics, fine chemicals, implant biomaterials, medicines and biofuels have been developed and are covered in this critical review. Companies have been established or involved in PHA related R&D as well as large scale production. Recently, bacterial PHA synthesis has been found to be useful for improving robustness of industrial microorganisms and regulating bacterial metabolism, leading to yield improvement on some fermentation products. In addition, amphiphilic proteins related to PHA synthesis including PhaP, PhaZ or PhaC have been found to be useful for achieving protein purification and even specific drug targeting. It has become clear that PHA and its related technologies are forming an industrial value chain ranging from fermentation, materials, energy to medical fields (142 references).
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            Biorefineries for the production of top building block chemicals and their derivatives.

            Due to the growing concerns on the climate change and sustainability on petrochemical resources, DOE selected and announced the bio-based top 12 building blocks and discussed the needs for developing biorefinery technologies to replace the current petroleum based industry in 2004. Over the last 10 years after its announcement, many studies have been performed for the development of efficient technologies for the bio-based production of these chemicals and derivatives. Now, ten chemicals among these top 12 chemicals, excluding the l-aspartic acid and 3-hydroxybutyrolactone, have already been commercialized or are close to commercialization. In this paper, we review the current status of biorefinery development for the production of these platform chemicals and their derivatives. In addition, current technological advances on industrial strain development for the production of platform chemicals using micro-organisms will be covered in detail with case studies on succinic acid and 3-hydroxypropionic acid as examples.
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              Epidemiology and Ecology of Opportunistic Premise Plumbing Pathogens: Legionella pneumophila, Mycobacterium avium, and Pseudomonas aeruginosa

              Background Legionella pneumophila, Mycobacterium avium, and Pseudomonas aeruginosa are opportunistic premise plumbing pathogens (OPPPs) that persist and grow in household plumbing, habitats they share with humans. Infections caused by these OPPPs involve individuals with preexisting risk factors and frequently require hospitalization. Objectives The objectives of this report are to alert professionals of the impact of OPPPs, the fact that 30% of the population may be exposed to OPPPs, and the need to develop means to reduce OPPP exposure. We herein present a review of the epidemiology and ecology of these three bacterial OPPPs, specifically to identify common and unique features. Methods A Water Research Foundation–sponsored workshop gathered experts from across the United States to review the characteristics of OPPPs, identify problems, and develop a list of research priorities to address critical knowledge gaps with respect to increasing OPPP-associated disease. Discussion OPPPs share the common characteristics of disinfectant resistance and growth in biofilms in water distribution systems or premise plumbing. Thus, they share a number of habitats with humans (e.g., showers) that can lead to exposure and infection. The frequency of OPPP-infected individuals is rising and will likely continue to rise as the number of at-risk individuals is increasing. Improved reporting of OPPP disease and increased understanding of the genetic, physiologic, and structural characteristics governing the persistence and growth of OPPPs in drinking water distribution systems and premise plumbing is needed. Conclusions Because broadly effective community-level engineering interventions for the control of OPPPs have yet to be identified, and because the number of at-risk individuals will continue to rise, it is likely that OPPP-related infections will continue to increase. However, it is possible that individuals can take measures (e.g., raise hot water heater temperatures and filter water) to reduce home exposures. Citation Falkinham JO III, Hilborn ED, Arduino MJ, Pruden A, Edwards MA. 2015. Epidemiology and ecology of opportunistic premise plumbing pathogens: Legionella pneumophila, Mycobacterium avium, and Pseudomonas aeruginosa. Environ Health Perspect 123:749–758; http://dx.doi.org/10.1289/ehp.1408692
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                2016
                8 December 2016
                : 11
                : 12
                : e0168051
                Affiliations
                [1 ]Argonne Associate of Seville, Environmental Science Division, Argonne National Laboratory, Argonne, Illinois, United States of America
                [2 ]National Homeland Security Research Center, U.S. Environmental Protection Agency, Cincinnati, Ohio, United States of America
                [3 ]Global Security Sciences Division, Argonne National Laboratory, Argonne, Illinois, United States of America
                Purdue University, UNITED STATES
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                • Conceptualization: MJD RJ.

                • Data curation: RJ.

                • Formal analysis: MJD.

                • Funding acquisition: RJ.

                • Investigation: MJD RJ.

                • Methodology: MJD.

                • Project administration: RJ.

                • Resources: RJ.

                • Software: RJ TNT.

                • Validation: MJD RJ TNT.

                • Visualization: MJD.

                • Writing – original draft: MJD RJ.

                • Writing – review & editing: MJD RJ TNT.

                Article
                PONE-D-16-33949
                10.1371/journal.pone.0168051
                5145240
                27930709
                2b670f56-1a29-48c8-82ab-092e05b37a0a

                This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

                History
                : 24 August 2016
                : 24 November 2016
                Page count
                Figures: 15, Tables: 9, Pages: 41
                Funding
                Work at Argonne National Laboratory was sponsored by the U.S. Environmental Protection Agency under interagency agreement through U.S. Department of Energy Contract DE-AC02-06CH11357. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Physical Sciences
                Materials Science
                Materials by Attribute
                Contaminants
                Biology and Life Sciences
                Physiology
                Physiological Processes
                Respiration
                Inhalation
                Medicine and Health Sciences
                Physiology
                Physiological Processes
                Respiration
                Inhalation
                Physical Sciences
                Materials Science
                Materials by Structure
                Mixtures
                Aerosols
                Physical Sciences
                Physics
                Classical Mechanics
                Continuum Mechanics
                Fluid Mechanics
                Fluid Dynamics
                Flow Rate
                Engineering and Technology
                Environmental Engineering
                Water Management
                Engineering and Technology
                Environmental Engineering
                Pollution
                Water Pollution
                Biology and Life Sciences
                Physiology
                Physiological Processes
                Ingestion
                Medicine and Health Sciences
                Physiology
                Physiological Processes
                Ingestion
                Biology and Life Sciences
                Physiology
                Physiological Processes
                Respiration
                Breathing
                Medicine and Health Sciences
                Physiology
                Physiological Processes
                Respiration
                Breathing
                Custom metadata
                All relevant data are within the paper and its Supporting Information files.

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