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      Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus.

      Journal of Ethnopharmacology
      Agaricales, Animals, Anti-Inflammatory Agents, Non-Steroidal, isolation & purification, therapeutic use, Butanols, Chick Embryo, Dose-Response Relationship, Drug, Edema, drug therapy, Male, Mice, Mice, Inbred ICR, Plant Extracts

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          This study aimed to elucidate the anti-inflammatory and related activities of mushroom Phellinus linteus. The results show that the EtOH extract of Phellinus linteus (PLE) dose-dependently inhibited the mouse ear edema induced by croton oil. Among PLE subfractions, the n-BuOH subfraction showed highest anti-inflammatory activity in croton oil-induced ear edema test. The n-BuOH subfraction also showed highest inhibitory activity on the chick embryo chorioallantoic membrane (CAM) angiogenesis in a dose-dependent manner. PLE could significantly reduce the number of writhing induced by acetic acid in mice, indicating that PLE possesses potent antinociceptive effect mediated by its anti-inflammatory activity. Mycelial extract of six different Phellinus strains were found to contain anti-angiogenic activity in the CAM assay. These results suggest that Phellinus linteus has anti-inflammatory and antinociceptive activities, in addition to its anti-angiogenic activity.

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