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Tumour stem cells and drug resistance.

Nature reviews. Cancer

physiology, Trans-Activators, Signal Transduction, Pluripotent Stem Cells, Neoplastic Stem Cells, Models, Animal, Mice, Humans, Hedgehog Proteins, Drug Resistance, Neoplasm, Cell Lineage, pharmacology, Antineoplastic Agents, Animals, ATP-Binding Cassette Transporters

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      Abstract

      The contribution of tumorigenic stem cells to haematopoietic cancers has been established for some time, and cells possessing stem-cell properties have been described in several solid tumours. Although chemotherapy kills most cells in a tumour, it is believed to leave tumour stem cells behind, which might be an important mechanism of resistance. For example, the ATP-binding cassette (ABC) drug transporters have been shown to protect cancer stem cells from chemotherapeutic agents. Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anticancer strategies.

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      Journal
      10.1038/nrc1590
      15803154

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