• Record: found
  • Abstract: found
  • Article: not found

Tumour stem cells and drug resistance.

Nature reviews. Cancer

physiology, Trans-Activators, Signal Transduction, Pluripotent Stem Cells, Neoplastic Stem Cells, Models, Animal, Mice, Humans, Hedgehog Proteins, Drug Resistance, Neoplasm, Cell Lineage, pharmacology, Antineoplastic Agents, Animals, ATP-Binding Cassette Transporters

Read this article at

      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


      The contribution of tumorigenic stem cells to haematopoietic cancers has been established for some time, and cells possessing stem-cell properties have been described in several solid tumours. Although chemotherapy kills most cells in a tumour, it is believed to leave tumour stem cells behind, which might be an important mechanism of resistance. For example, the ATP-binding cassette (ABC) drug transporters have been shown to protect cancer stem cells from chemotherapeutic agents. Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anticancer strategies.

      Related collections

      Author and article information



      Comment on this article