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      Hidden blood loss and its influential factors after total hip arthroplasty

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          Abstract

          Background

          Total hip arthroplasty (THA) is a vital therapy for various hip joint diseases. However, patients have lower hemoglobin level post-operatively, remarkably inconsistent with the measured blood loss. The inconsistence is majorly attributed to hidden blood loss (HBL). In this study, we investigated the HBL and its influential factors among patients after THA.

          Methods

          From January 2008 to June 2014, 322 patients (99 males and 223 females) undergoing THA were enrolled in this study. All patients were assessed comprehensively before the operation. The demographic information of the patients was collected. Intra-operative and post-operative blood loss was recorded, and then, the total perioperative blood loss and the HBL were calculated. Influential factors were further analyzed by multiple and stepwise regression.

          Results

          The HBL was 429 ± 223 mL, with a percentage of 35.4% ± 11.0% in the total perioperative blood loss (1,155 ± 377 mL). Multiple and stepwise regression analysis revealed that HBL was positively associated with body mass index (BMI), blood transfusion volume, length of incision, change of hematocrit (HCT) between pre-operation and post-operation but negatively associated with age. As compared to male patients, female patients had a risk of increased HBL. Development displasia hip (DDH) patients had a less risk of HBL in all patients.

          Conclusion

          HBL is a significant portion of total blood loss in the patients after THA. Gender, age, BMI, blood transfusion, length of incision, change of HCT, and diagnosis are influential factors of HBL.

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          Most cited references27

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          Estimating allowable blood loss: corrected for dilution.

          J B Gross (1983)
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            Hidden blood loss following hip and knee arthroplasty. Correct management of blood loss should take hidden loss into account.

            Following total hip arthroplasty (THA) and total knee arthroplasty (TKR) only the 'visible' measured blood loss is usually known. This underestimates the 'true' total loss, as some loss is 'hidden'. Correct management of blood loss should take hidden loss into account. We studied 101 THAs and 101 TKAs (with re-infusion of drained blood). Following THA, the mean total loss was 1510 ml and the hidden loss 471 ml (26%). Following TKA, the mean total loss was 1498 ml. The hidden loss was 765 ml (49%). Obesity made no difference with either operation. THA involves a small hidden loss, the total loss being 1.3 times that measured. However, following TKA, there may be substantial hidden blood loss due to bleeding into the tissues and residual blood in the joint. The true total loss can be determined by doubling the measured loss.
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              How much blood is really lost in total knee arthroplasty?. Correct blood loss management should take hidden loss into account.

              In total knee arthroplasty (TKA) the total blood loss is composed of 'visible' blood loss from the surgical field and wound drainage, and blood loss into the tissues which is hidden. Blood management should be aimed at addressing the total blood loss. The measured loss is generally an underestimation of the 'true' loss, which can be calculated. Sixty-three TKAs were prospectively studied at the Avon Orthopaedic Centre, Bristol, UK. All but two TKAs were performed under a tourniquet. Thus the intraoperative blood loss was usually zero. Reinfusion of drained blood was carried out when appropriate. The drainage and volume reinfused were recorded. None of the patients studied received a bank blood transfusion. All patients had FBC including haematocrit (Hct) pre- and post-operatively. Each patients height and weight were recorded pre-operatively. The true total blood loss was calculated using height, weight and pre- and post-op Hct. Subtracting the visible loss gives the hidden loss. As the object of the study was to determine the proportion of blood loss that is hidden, rather than document blood loss in general, seven patients with very large blood losses were excluded from the study to minimise the effect of haemodilution on our calculation. The threshold chosen was 1.5 l. In TKA, the mean total calculated blood loss was 1474 ml. The mean hidden loss was 735 ml. It can be seen that the hidden loss is 50% of the total loss, making the true loss following TKA twice the volume usually recorded. This is due to bleeding into the tissues and haemolysis when reinfusion is carried out. It is concluded that when planning blood management after TKA, account should be taken of the probable substantial hidden blood loss.
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                Author and article information

                Contributors
                miaokaisong@163.com
                vivian.nisu@gmail.com
                hippocampus2007@gmail.com
                xunanwei1963@aliyun.com
                275585025@qq.com
                zhuangchao911@163.com
                yujiwang@sohu.com
                Journal
                J Orthop Surg Res
                J Orthop Surg Res
                Journal of Orthopaedic Surgery and Research
                BioMed Central (London )
                1749-799X
                18 March 2015
                18 March 2015
                2015
                : 10
                : 36
                Affiliations
                [ ]Department of Orthopaedics, Changzhou No.2 People’s Hospital, the Affiliated Hospital of Nanjing Medical University, 29 Xinglong Alley, Changzhou, 213003 People’s Republic of China
                [ ]Laboratory of Clinical Orthopaedics, Department of Orthopaedics, Changzhou No.2 People’s Hospital, the Affiliated Hospital of Nanjing Medical University, 29 Xinglong Alley, Changzhou, 213003 People’s Republic of China
                [ ]Laboratory of Neurological Diseases, Department of Neurology, Changzhou No.2 People’s Hospital, the Affiliated Hospital of Nanjing Medical University, 29 Xinglong Alley, Changzhou, 213003 People’s Republic of China
                Article
                185
                10.1186/s13018-015-0185-9
                4367912
                25889223
                2bae35f5-1e98-4be4-92b0-73fd05014751
                © Miao et al.; licensee BioMed Central. 2015

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 10 November 2014
                : 13 January 2015
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2015

                Surgery
                hidden blood loss,influential factors,total hip arthroplasty,gross formula,multiple and stepwise regression

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