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3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial
Carel W le Roux ,
Arne Astrup ,
Ken Fujioka ,
Frank Greenway ,
David C W Lau ,
Luc Van Gaal ,
Rafael Violante Ortiz ,
John P H Wilding ,
Trine V Skjøth ,
Linda Shapiro Manning ,
Xavier Pi-Sunyer ,
Andreas Hamann ,
Alain Barakat ,
Matthias Blüher ,
Thomas Linn ,
Andrea Mölle ,
Alexander Segner ,
Petra Stübler ,
Regina Tosch-Sisting ,
Furio Pacini ,
Ferruccio Santini ,
Giulio Marchesini ,
Carlo Maria Rotella ,
Cecilia Invitti ,
Roberto Vettor ,
Silvio Buscemi ,
Pedro Mezquita Raya ,
Felipe Casanueva Freijoo ,
Ramón Gomis de Barbará ,
Raffaele Carraro ,
Enrique Romero Bobillo ,
Carmen de la Cuesta ,
Csaba Farsang ,
Albert Csaszar ,
Barbara Zahorska-Markiewicz ,
Danuta Pupek-Musialik ,
Edward Franek ,
Lucyna Ostrowska ,
Magdalena Olszanecka-Glinianowicz ,
Nebojsa Lalic ,
Dragan Micic ,
Bernhard Ludvik ,
Bernhard Paulweber ,
Rudolf Prager ,
André Scheen ,
Luc Van Gaal ,
Arne Vernon Astrup ,
Kjeld Hermansen ,
Sten Madsbad ,
Aila Rissanen ,
Sakari Nieminen ,
Markku Savolainen ,
Michel Krempf ,
Monique Romon ,
Martine Laville ,
Michel Marre ,
Reginald Mira ,
Francis Finucane ,
Aletha Veenendaal ,
Frank van Berkum ,
Solrun Johannsson-Vidarsdóttir ,
Vivienne Van de Walle ,
Eelco Meesters ,
Jøran Hjelmesæth ,
Tor Ole Klemsdal ,
Bård Kulseng ,
Birgit Bach-Kliegel ,
Kurt Laederach ,
Lukas Villiger ,
Alain Golay ,
Stefan Bilz ,
Thozhukat Sathyapalan ,
Stephen Bain ,
Sudesh Kumar ,
Carel Wynard Le Roux ,
Michael E.J. Lean ,
Barbara McGowan ,
Tariq Rehman ,
John Wilding ,
Gary Wittert ,
Ian Caterson ,
Joeseph Proietto ,
John Prins ,
Bruno Geloneze Neto ,
Jorge Luiz Gross ,
Antonio Roberto Chacra ,
Alfredo Halpern ,
Henrique de Almeida Suplicy ,
Francis Chun Chung Chow ,
Hemant P Thacker ,
Manoj Chadha ,
Hemaraj Chandalia ,
Ambika Unnikrishnan ,
Sanjay Kalra ,
Neeta Deshpande ,
Minakshi Shunmugavelu ,
Vaishali Chetan Deshmukh ,
Maximo Maislos ,
Gabriella Segal Lieberman ,
Ilan Shimon ,
Naftali Stern ,
Dan Nabriski ,
Eddy Karnieli ,
Naim Shehadeh ,
Guillermo Gonzalez-Galvez ,
Maria del Rosario Arechavaleta-Granell ,
Rafael Margarito Violante Ortiz ,
Guadalupe Morales Franco ,
Irina Gurieva ,
Lyudmila Aleksandrovna Suplotova ,
Ekaterina Troshina ,
Ludmila Aleksandrovna Ruyatkina ,
Emma Anatolievna Voychik ,
Sergey Martsevich ,
Maria A Startseva ,
Mary Elizabeth Seeber ,
Aysha Badat ,
Graham Ellis ,
Yuksel Altuntas ,
Serdar Guler ,
Ender Ulgen ,
Tuncay Delibasi ,
Tony Chetty ,
Randy Hart ,
Jeannette Janzen ,
Isabelle Labonte ,
David Lau ,
Joanne Liutkus ,
Dennis O'Keefe ,
Raj Padwal ,
Thomas P.P. Ransom ,
Richard Tytus ,
Stanley John Weisnagel ,
Jay Adler ,
Keith Aqua ,
Stephen L Aronoff ,
Gary W. Bedel ,
Thomas Craig Blevins ,
Joe Blumenau ,
Andrew Peter Brockmyre ,
Robert S Call ,
Rafael Canadas ,
Louis B Chaykin ,
Kenneth Cohen ,
Jeffrey Keith Conrow ,
Matthew G Davis ,
H Jackson Downey ,
Steven Richard Drosman ,
Steven Duckor ,
H. Frank Farmer ,
James Farrell ,
Stephen Fehnel ,
Matthew Patrick Finneran ,
Ray Forbes ,
Alan Forker ,
Mark Fredrick ,
Ken Fujioka ,
Steven Andrew Geller ,
Santosh Gill ,
Linda Glaser ,
Susan Neims Greco ,
Frank Lyons Greenway ,
Wayne Harper ,
Lee Herman ,
John Hoekstra ,
Richard Ingebretsen ,
Rodney Ison ,
Rajeev K Jain ,
Roy Kaplan ,
Steven Richard Kaster ,
Gregory A Haase ,
Boris Kerzner ,
Judith Lee Kirstein ,
William Koltun ,
Diane R Krieger ,
Cora Elizabeth Lewis ,
Robert Madder ,
Richard N Marple ,
Edward J McDermott ,
Curtis John Mello ,
Alan B. Miller ,
Julie Mullen ,
John Nardandrea ,
Patrick O'Neil ,
F. Xavier Pi-Sunyer ,
Ronald M Pucillo ,
Chanhaeng Rhee ,
Scott Redrick ,
Aaron Pardini ,
Jeffrey Rothman ,
Domenica Marie Rubino ,
Gladstone Sellers ,
Timothy Smith ,
William David Byars ,
Joseph Soufer ,
Allen Michael Sussman ,
Kyle Patrick ,
Erich Lloyd Schramm ,
Martin Van Cleeff ,
Saul Reuel Berg ,
Holly Roxanna Wyatt ,
James Alan Simon
April 2017
April 2017
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Abstract
Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose metabolism after
the 56-week period of this trial, one of four trials in the SCALE programme. In the
3-year assessment of the SCALE Obesity and Prediabetes trial we aimed to evaluate
the proportion of individuals with prediabetes who were diagnosed with type 2 diabetes.