Dexmedetomidine Exerts an Anti-inflammatory Effect via α2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice.

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Abstract

Clinical studies have shown that dexmedetomidine ameliorates cognitive decline in both the postoperative and critical care settings. This study determined the mechanism(s) for the benefit provided by dexmedetomidine in a medical illness in mice induced by lipopolysaccharide.

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Journal

Journal ID (iso-abbrev): Anesthesiology

Title: Anesthesiology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1528-1175

ISSN (Print): 0003-3022

Publication date (Electronic): August 2020

Volume: 133

Issue: 2

Affiliations

[1 ] From the Department of Anesthesiology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (R.L., P.Z.) the Center for Brain Science, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (R.L.) the Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care (R.L., I.K.L., J.Z.P., M.M.) the Brain and Spinal Injury Center (J.Z.P.), University of California, San Francisco, California.

Article

DOI: 10.1097/ALN.0000000000003390

PubMed ID: 32482998

SO-VID: 2bcbc5af-5007-4ee8-ab45-926a0cfb1d87

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