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      Neurological soft signs and dermatoglyphic anomalies in twins with schizophrenia.

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          Abstract

          Schizophrenia is associated with altered neural development. We assessed neurological soft signs (NSS) and dermatoglyphic anomalies (total a-b ridge count (TABRC) and total finger ridge count) in 15 pairs of twins concordant and discordant for schizophrenia. Within-pair differences in both NSS and TABRC scores were significantly greater in discordant compared to concordant monozygotic pairs. There was no significant difference in NSS and TABRC scores between subjects with schizophrenia and their co-twins without the illness. However, monozygotic discordant twins with schizophrenia had higher ABRCs on their right hands compared to their co-twins without the illness. These findings suggest that an unidentified environmental event acting between weeks 6 and 15 of gestation affects the development of monozygotic twins who go on to develop schizophrenia but does not have a corresponding effect on their co-twins who do not develop the illness. The effect of such an event on dermatoglyphic profiles appears lateralised to the right hand in affected twins.

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          Author and article information

          Journal
          Eur. Psychiatry
          European psychiatry : the journal of the Association of European Psychiatrists
          Elsevier BV
          0924-9338
          0924-9338
          May 2004
          : 19
          : 3
          Affiliations
          [1 ] Department of Adult Psychiatry, Hospitaller Order of St John of God, Cluain Mhuire Service, Co Dublin, Ireland.
          Article
          S0924933804000240
          10.1016/j.eurpsy.2003.10.006
          15158923

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