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      Differences in Sensitivity to Microstructure between Cyclic- and Impact-Based Microindentation of Human Cortical Bone

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          Abstract

          Unlike the known relationships between traditional mechanical properties and microstructural features of bone, the factors that influence the mechanical resistance of bone to cyclic reference point microindention (cRPI) and impact microindention (IMI) have yet to be identified. To determine whether cRPI and IMI properties depend on microstructure, we indented the tibia mid-shaft, the distal radius, and the proximal humerus from 10 elderly donors using the BioDent and OsteoProbe (neighboring sites). As the only output measure of IMI, bone material strength index (BMSi) was significantly different across all 3 anatomical sites being highest for the tibia mid-shaft and lowest for the proximal humerus. Total indentation distance (inverse of BMSi) was higher for the proximal humerus than for the tibia mid-shaft but was not different between other anatomical comparisons. As a possible explanation for the differences in BMSi, pore water, as determined by 1H nuclear magnetic resonance, was lowest for the tibia and highest for the humerus. Moreover, the local intra-cortical porosity, as determined by micro-computed tomography, was negatively correlated with BMSi for both arm bones. BMSi was however positively correlated with peak bending stress of cortical bone extracted from the tibia mid-shaft. Microstructural correlations with cRPI properties were not significant for any of the bones. The one exception was that average energy dissipated during cRPI was negatively correlated with local tissue mineral density in the tibia mid-shaft. With higher indentation force and larger tip diameter than cRPI, only IMI appears to be sensitive to the underlying porosity of cortical bone.

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          Author and article information

          Journal
          8404726
          5097
          J Orthop Res
          J. Orthop. Res.
          Journal of orthopaedic research : official publication of the Orthopaedic Research Society
          0736-0266
          1554-527X
          20 June 2017
          04 October 2016
          July 2017
          01 July 2018
          : 35
          : 7
          : 1442-1452
          Affiliations
          [1 ]Department of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, Nashville, TN 37232
          [2 ]Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37232
          [3 ]Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37232
          [4 ]Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232
          [5 ]Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212
          Author notes
          Contact: Jeffry S. Nyman, 1215 21 st Ave. S., Suite 4200, Nashville, TN 37232, jeffry.s.nyman@ 123456vanderbilt.edu , office: (615) 936-6296, fax: (615) 936-0117
          Article
          PMC5530367 PMC5530367 5530367 nihpa884173
          10.1002/jor.23392
          5530367
          27513922
          2bdab5da-b376-4526-8c56-101232959d8d
          Categories
          Article

          bound water,reference point indentation,pore water,porosity,bone strength

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