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Abstract
There are few clinicopathologic and outcome data on patients with crescentic lupus
nephritis, therefore, we determined factors of the disease by retrospectively reviewing
the records of 327 patients diagnosed with lupus nephritis. Of these, 152 cases were
regrouped as class IV-G, including 33 patients with crescentic glomerulonephritis.
Significantly, all patients with crescentic glomerulonephritis had acute kidney injury
as compared with only about a quarter of the patients without the disease. On pathological
evaluation, activity scores, chronicity indexes, relapse rates, and the frequency
of positive serum anti-neutrophil cytoplasmic antibody (ANCA) were each significantly
higher, whereas complete remission rates and renal outcomes, over a mean follow-up
of 4 years, were significantly poorer in patients with crescentic glomerulonephritis.
Our study shows that crescentic glomerulonephritis was not rare in patients with lupus
nephritis and that their long-term outcome was poor. The precise role of ANCA in the
pathologic course of crescentic lupus nephritis remains to be determined.