54
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress.

      Science (New York, N.Y.)

      Adrenocorticotropic Hormone, blood, Animals, Animals, Newborn, Corticosterone, pharmacology, Corticotropin-Releasing Hormone, genetics, Feedback, Female, Gene Expression Regulation, Grooming, Handling (Psychology), Hippocampus, physiology, Hypothalamo-Hypophyseal System, Maternal Behavior, Pituitary-Adrenal System, RNA, Messenger, metabolism, Rats, Receptors, Glucocorticoid, Stress, Physiological, physiopathology

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Variations in maternal care affect the development of individual differences in neuroendocrine responses to stress in rats. As adults, the offspring of mothers that exhibited more licking and grooming of pups during the first 10 days of life showed reduced plasma adrenocorticotropic hormone and corticosterone responses to acute stress, increased hippocampal glucocorticoid receptor messenger RNA expression, enhanced glucocorticoid feedback sensitivity, and decreased levels of hypothalamic corticotropin-releasing hormone messenger RNA. Each measure was significantly correlated with the frequency of maternal licking and grooming (all r's > -0.6). These findings suggest that maternal behavior serves to "program" hypothalamic-pituitary-adrenal responses to stress in the offspring.

          Related collections

          Author and article information

          Journal
          9287218

          Comments

          Comment on this article