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      Clinical Efficacy Evaluation and Potential Mechanism of Zhishe Tongluo Capsule in the Treatment of Cerebral Infarction by Meta-Analysis Associated with Network Pharmacology

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          Abstract

          Objective

          By integrating meta-analysis and network pharmacology strategy, the clinical efficacy of Zhishe Tongluo capsule in the treatment of cerebral infarction was evaluated, and the intervention mechanism was preliminary explored.

          Methods

          Through meta-analysis, the Chinese and English literature of the randomized controlled trial (RCT) of Zhishe Tongluo capsule in the treatment of cerebral infarction was comprehensively searched. Based on the standard of Na Pai, the quantitative literature was determined and the Review Manager data were statistically analyzed.

          Results

          A total of 10 RCTs literatures were included. These literatures included a total of 1278 subjects, of which 670 were in the treatment group and 608 were in the control group. In terms of indicators of efficiency and adverse reaction rate, the treatment group was better than the control group. There was a statistical difference ( P < 0.05); a total of 559 chemical constituents and 2306 potential targets were obtained from the online database. Of these, 201 components, 145 targets, and 185 pathways were closely related to cerebral infarction.

          Conclusions

          The available evidence indicates that the addition of Zhishe Tongluo capsule to the conventional treatment of Western medicine can improve the clinical efficacy of cerebral infarction and has some advantages in regulating blood lipids and hemorheology, but the overall evidence level is low, which still needs to be further supported by large-scale and multicenter RCTs; intervention of brain infarction by Zhishe Tongluo capsule is a comprehensive result of multicomponent and multi-target interactions. On the basis of the combined meta-analysis and network pharmacology in scientific attempts, it also provides a reference for the clinical evaluation of other drugs and mechanism research.

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          Most cited references52

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              Abstract The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this article, we describe significant updates that we have made over the last two years to the resource. The number of sequences in UniProtKB has risen to approximately 190 million, despite continued work to reduce sequence redundancy at the proteome level. We have adopted new methods of assessing proteome completeness and quality. We continue to extract detailed annotations from the literature to add to reviewed entries and supplement these in unreviewed entries with annotations provided by automated systems such as the newly implemented Association-Rule-Based Annotator (ARBA). We have developed a credit-based publication submission interface to allow the community to contribute publications and annotations to UniProt entries. We describe how UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.
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                Author and article information

                Contributors
                Journal
                Evid Based Complement Alternat Med
                Evid Based Complement Alternat Med
                ECAM
                Evidence-based Complementary and Alternative Medicine : eCAM
                Hindawi
                1741-427X
                1741-4288
                2022
                10 January 2022
                10 January 2022
                : 2022
                : 2471927
                Affiliations
                1Shannxi University of Chinese Medicine, Xianyang 712046, China
                2Shaanxi Jianmin Pharmaceutical Co Ltd, Xianyang 712021, China
                3The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
                Author notes

                Academic Editor: Talha Bin Emran

                Author information
                https://orcid.org/0000-0002-9741-4896
                https://orcid.org/0000-0002-2712-4244
                https://orcid.org/0000-0002-8652-5312
                Article
                10.1155/2022/2471927
                8763521
                35047043
                2c13ab8e-f53e-4d07-b2d1-6e240b40c0a2
                Copyright © 2022 Zhi Xin Geng et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 23 July 2021
                : 15 December 2021
                : 22 December 2021
                Funding
                Funded by: Shaanxi University of Chinese Medicine
                Award ID: 2020XKTD-A04
                Award ID: 2019-QN02
                Funded by: Shaanxi University of Traditional Chinese Medicine Clinical Medicine Excellence Discipline Team
                Award ID: ZYTD-04
                Funded by: Research on Identification Technology of Efficacy Substances of Zhishe Tongluo Capsules Based on Integrated Pharmacological Strategy
                Award ID: 2019ZDLSF04-04-01
                Categories
                Research Article

                Complementary & Alternative medicine
                Complementary & Alternative medicine

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