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      Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma.

      Science (New York, N.Y.)
      Adrenal Glands, drug effects, Adrenocorticotropic Hormone, blood, Animals, Biological Assay, Cushing Syndrome, Hormones, Humans, Hypopituitarism, Iodine Isotopes, Methods, Peptides, Radioimmunoassay, Receptors, Drug, Swine

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          Abstract

          Biologically active iodine-125-labeled adrenocorticotropic hormone (ACTH) binds specifically to ACTH receptors extracted from adrenals. Unlabeled ACTH at 1 picogram per milliliter significantly displaces labeled ACTH from these receptors. This system, which appears to be applicable to all polypeptide hormones, provides a rapid and sensitive method for measurements of biologically active ACTH in dilute whole plasma.

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