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      Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis

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          Abstract

          Background

          The efficacy of sivelestat in the treatment of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has not been established. In part, this is due to the wide variety of factors involved in the etiology of ALI/ARDS. In this study, we examined the efficacy of sivelestat in patients with ALI/ARDS associated with abdominal sepsis.

          Methods

          The subjects were 49 patients with ALI/ARDS after surgery for abdominal sepsis. The efficacy of sivelestat was retrospectively assessed in two treatment groups, ie, a sivelestat group (n = 34) and a non-sivelestat group (n = 15).

          Results

          The sivelestat group showed significant improvements in oxygenation, thrombocytopenia, and multiple organ dysfunction score. The number of ventilator days (6.6 ± 6.1 versus 11.1 ± 8.4 days; P = 0.034) and length of stay in the intensive care unit (8.5 ± 6.2 versus 13.3 ± 9.5 days; P = 0.036) were significantly lower in the sivelestat group. The hospital mortality rate decreased by half in the sivelestat group, but was not significantly different between the two groups.

          Conclusion

          Administration of sivelestat to patients with ALI/ARDS following surgery for abdominal sepsis resulted in early improvements of oxygenation and multiple organ dysfunction score, early ventilator weaning, and early discharge from the intensive care unit.

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          Author and article information

          Journal
          Drug Des Devel Ther
          Drug Des Devel Ther
          Drug Design, Development and Therapy
          Dove Medical Press
          1177-8881
          2012
          10 October 2012
          : 6
          : 273-278
          Affiliations
          [1 ]Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
          [2 ]Intensive Care Unit and Cardiac Care Unit, Nippon Medical School Hospital, Tokyo, Japan
          [3 ]Department of Surgery, Nippon Medical School, Tokyo, Japan
          Author notes
          Correspondence: Yoshiaki Tsuboko, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan, Tel +813 5814 6243, Fax +813 5685 3077, Email tsubo-yossy@ 123456nms.ac.jp
          Article
          dddt-6-273
          10.2147/DDDT.S36436
          3471461
          23091371
          © 2012 Tsuboko et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Original Research

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