In vivo detection of hyperoxia-induced pulmonary endothelial cell death using (99m)Tc-duramycin.

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Abstract

(99m)Tc-duramycin, DU, is a SPECT biomarker of tissue injury identifying cell death. The objective of this study is to investigate the potential of DU imaging to quantify capillary endothelial cell death in rat lung injury resulting from hyperoxia exposure as a model of acute lung injury.

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Author and article information

Journal

Journal ID (iso-abbrev): Nucl. Med. Biol.

Title: Nuclear medicine and biology

ISSN (Electronic): 1872-9614

ISSN (Print): 0969-8051

Publication date (Electronic): Jan 2015

Volume: 42

Issue: 1

Affiliations

[1 ] Department of Biomedical Engineering, Marquette University; Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin.

[2 ] Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin; Zablocki V.A. Medical Center.

[3 ] Division of Cardiology, Feinberg School of Medicine, Northwestern University.

[4 ] Zablocki V.A. Medical Center; Department of Anesthesiology, Medical College of Wisconsin; Department of Pharmacology/Toxicology, Medical College of Wisconsin.

[5 ] Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin.

[6 ] Department of Biomedical Engineering, Marquette University; Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin; Department of Mathematics, Statistics, and Computer Science, Marquette University. Electronic address: anne.clough@marquette.edu.

Article

Publisher Item ID: S0969-8051(14)00485-5 Mid ID: NIHMS627753

DOI: 10.1016/j.nucmedbio.2014.08.010

PMC ID: 4383294

PubMed ID: 25218023

SO-VID: 2c3b94c7-cd20-4424-aa5b-b9cdf8d33dac

History

Keywords: Acute lung injury,Apoptosis,Lung imaging

Data availability:

Keywords: Acute lung injury, Apoptosis, Lung imaging

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