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      A multi-family cluster of COVID-19 associated with asymptomatic and pre-symptomatic transmission in Jixi City, Heilongjiang, China, 2020

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          ABSTRACT

          We investigated a multi-family cluster of 22 cases in Jixi, where pre-symptomatic and asymptomatic transmission resulted in at least 41% of household infections of SARS-CoV-2. Our study illustrates the challenge of controlling COVID-19 due to the presence of asymptomatic and pre-symptomatic transmission even when extensive testing and contact tracing are conducted.

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          Presumed Asymptomatic Carrier Transmission of COVID-19

          Yan Bai, Lingsheng Yao, Tao Wei … (2020)
          This study describes possible transmission of novel coronavirus disease 2019 (COVID-19) from an asymptomatic Wuhan resident to 5 family members in Anyang, a Chinese city in the neighboring province of Hubei.
          Article 0 comments Cited 1971 times – based on 0 reviews     Review now
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            Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2)

            Ruiyun Li, Sen Pei, Bin Chen … (2020)
            Estimation of the prevalence and contagiousness of undocumented novel coronavirus (SARS-CoV2) infections is critical for understanding the overall prevalence and pandemic potential of this disease. Here we use observations of reported infection within China, in conjunction with mobility data, a networked dynamic metapopulation model and Bayesian inference, to infer critical epidemiological characteristics associated with SARS-CoV2, including the fraction of undocumented infections and their contagiousness. We estimate 86% of all infections were undocumented (95% CI: [82%–90%]) prior to 23 January 2020 travel restrictions. Per person, the transmission rate of undocumented infections was 55% of documented infections ([46%–62%]), yet, due to their greater numbers, undocumented infections were the infection source for 79% of documented cases. These findings explain the rapid geographic spread of SARS-CoV2 and indicate containment of this virus will be particularly challenging.
            Article 0 comments Cited 1626 times – based on 0 reviews     Review now
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              Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020

              Kenji Mizumoto, Katsushi Kagaya, Alexander Zarebski … (2020)
              On 5 February 2020, in Yokohama, Japan, a cruise ship hosting 3,711 people underwent a 2-week quarantine after a former passenger was found with COVID-19 post-disembarking. As at 20 February, 634 persons on board tested positive for the causative virus. We conducted statistical modelling to derive the delay-adjusted asymptomatic proportion of infections, along with the infections’ timeline. The estimated asymptomatic proportion was 17.9% (95% credible interval (CrI): 15.5–20.2%). Most infections occurred before the quarantine start.
              Article 0 comments Cited 1083 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Emerg Microbes Infect
                Journal ID (iso-abbrev): Emerg Microbes Infect
                Title: Emerging Microbes & Infections
                Publisher: Taylor & Francis
                ISSN (Electronic): 2222-1751
                Publication date (Electronic, pub): 25 November 2020
                Publication date (Electronic, collection): 2020
                Volume: 9
                Issue: 1
                Pages: 2509-2514
                Affiliations
                [a ]Harbin Institute of Technology at Shenzhen , Guangdong, People’s Republic of China
                [b ]Heilongjiang Provincial Center for Disease Control and Prevention , Harbin, People’s Republic of China
                [c ]Johns Hopkins Bloomberg School of Public Health , Baltimore, MD, USA
                [d ]Jixi City Centre for Disease Control and Prevention , Jixi, People’s Republic of China
                [e ]Peng Cheng Laboratory , Shenzhen, People’s Republic of China
                Author notes
                [CONTACT ] Qifang Bi qbi1@ 123456jhu.edu ; Ting Ma tma@ 123456hit.edu.cn
                [#]

                These first authors contributed equally to this article.

                Author information
                https://orcid.org/0000-0001-6080-050X
                Article
                Publisher ID: 1837015
                DOI: 10.1080/22221751.2020.1837015
                PMC ID: 7717603
                PubMed ID: 33238813
                SO-VID: 2c3bf35b-84bb-4516-8364-e0cb1c57e408
                Copyright © © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Page count
                Figures: 1, Tables: 0, Equations: 0, References: 9, Pages: 6
                Categories
                Subject: Letter
                Subject: Letter

                Keywords: asymptomatic transmission,pre-symptomatic transmission,covid-19,cluster,household close contact,contact tracing
                Data availability:
                Keywords: asymptomatic transmission, pre-symptomatic transmission, covid-19, cluster, household close contact, contact tracing

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