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      Stability and compatibility of ondansetron with haloperidol in parenteral admixtures

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          Abstract

          Background

          The chemical stability of coadministered ondansetron (OND) and haloperidol (HAL) in parenteral admixtures has not been described yet.

          Objective

          The aim of the present work is to study the chemical stability and the compatibility of OND and HAL admixtures.

          Methods

          Normal saline solution and dextrose were used to prepare the admixture solutions of the drugs; the materials of the containers were the original plastic bags of the diluents and the stability was studied at 20°C. Compatibility was studied by visual inspection of no colour change and turbidity or precipitation appearance. The concentration of the drugs was studied by ultraviolet detection high-performance liquid chromatography. The method was validated following the Food and Drug Administration and European Medicines Agency guidelines, and the assay enables the measurement of both drugs with a linear calibration curve (r=0.999) over the concentration range 10–100 µg/mL, with acceptable values of linearity, precision and accuracy. Darunavir was used as internal standard.

          Results

          Most of the admixtures have an adequate concentration until 24 hours(less than 10% of loss). 25% of the samples show a higher loss at 24 hours, and the chemical stability of these samples is 12 hours.

          Conclusions

          The stability and compatibility of OND and HAL in the coadministered admixtures in Viaflo plastic bags with normal saline or dextrose are suggested at 12 hours.

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          Author and article information

          Journal
          Eur J Hosp Pharm
          Eur J Hosp Pharm
          ejhpharm
          ejhp
          European Journal of Hospital Pharmacy
          European Journal of Hospital Pharmacy (BMA House, Tavistock Square, London, WC1H 9JR )
          2047-9956
          2047-9964
          July 2018
          13 April 2017
          : 25
          : 4
          : 200-203
          Affiliations
          Servicio de Farmacia, Hospital General Universitario de Elche-FISABIO , Elche, Spain
          Author notes
          [Correspondence to ] Carmen Matoses-Chirivella, Servicio de Farmacia, Hospital General Universitario de Elche-FISABIO, Camino de la Almazara, nº 11, 03203, Elche, Spain; matoses_car@ 123456gva.es

          EAHP Statement 6: Education and Research

          Article
          PMC6452387 PMC6452387 6452387 ejhpharm-2016-001200
          10.1136/ejhpharm-2016-001200
          6452387
          31157019
          © European Association of Hospital Pharmacists (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
          Funding
          Funded by: European Regional Development Fund (ERDF) and the European Social Fund (ESF);
          Categories
          Original Article
          2345

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