Perfluoroalkyl acids (PFAAs) in the aquatic food web of a temperate urban lake in East China: Bioaccumulation, biomagnification, and probabilistic human health risk

Abstract The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in food. Regarding PFOS and PFOA occurrence, the final data set available for dietary exposure assessment contained a total of 20,019 analytical results (PFOS n = 10,191 and PFOA n = 9,828). There were large differences between upper and lower bound exposure due to analytical methods with insufficient sensitivity. The CONTAM Panel considered the lower bound estimates to be closer to true exposure levels. Important contributors to the lower bound mean chronic exposure were ‘Fish and other seafood’, ‘Meat and meat products’ and ‘Eggs and egg products’, for PFOS, and ‘Milk and dairy products’, ‘Drinking water’ and ‘Fish and other seafood’ for PFOA. PFOS and PFOA are readily absorbed in the gastrointestinal tract, excreted in urine and faeces, and do not undergo metabolism. Estimated human half‐lives for PFOS and PFOA are about 5 years and 2–4 years, respectively. The derivation of a health‐based guidance value was based on human epidemiological studies. For PFOS, the increase in serum total cholesterol in adults, and the decrease in antibody response at vaccination in children were identified as the critical effects. For PFOA, the increase in serum total cholesterol was the critical effect. Also reduced birth weight (for both compounds) and increased prevalence of high serum levels of the liver enzyme alanine aminotransferase (ALT) (for PFOA) were considered. After benchmark modelling of serum levels of PFOS and PFOA, and estimating the corresponding daily intakes, the CONTAM Panel established a tolerable weekly intake (TWI) of 13 ng/kg body weight (bw) per week for PFOS and 6 ng/kg bw per week for PFOA. For both compounds, exposure of a considerable proportion of the population exceeds the proposed TWIs.

Poly- and perfluoroalkyl substances (PFAS) comprise more than 4,000 anthropogenically manufactured compounds with widescale consumer and industrial applications. This critical review compiles the latest information on the worldwide distribution of PFAS and evaluates their fate in wastewater treatment plants (WWTPs). A large proportion (>30%) of monitoring studies in WWTPs were conducted in China, followed by Europe (30%) and North America (16%), whereas information is generally lacking for other parts of the world, including most of the developing countries. Short and long-chain perfluoroalkyl acids (PFAAs) were widely detected in both the influents (up to 1,000 ng/L) and effluents (15 to >1,500 ng/L) of WWTPs. To date, limited data is available regarding levels of PFAS precursors and ultra-short chain PFAS in WWTPs. Most WWTPs exhibited low removal efficiencies for PFAS, and many studies reported an increase in the levels of PFAAs after wastewater treatment. The analysis of the fate of various classes of PFAS at different wastewater treatment stages (aerobic and/aerobic biodegradation, photodegradation, and chemical degradation) revealed biodegradation as the primary mechanism responsible for the transformation of PFAS precursors to PFAAs in WWTPs. Remediation studies at full scale and laboratory scale suggest advanced processes such as adsorption using ion exchange resins, electrochemical degradation, and nanofiltration are more effective in removing PFAS (~95-100%) than conventional processes. However, the applicability of such treatments for real-world WWTPs faces significant challenges due to the scaling-up requirements, mass-transfer limitations, and management of treatment by-products and wastes. Combining more than one technique for effective removal of PFAS, while addressing limitations of the individual treatments, could be beneficial. Considering environmental concentrations of PFAS, cost-effectiveness, and ease of operation, nanofiltration followed by adsorption using wood-derived biochar and/or activated carbons could be a viable option if introduced to conventional treatment systems. However, the large-scale applicability of the same needs to be further verified.

Recent reviews by researchers from academia, industry, and government have revealed that the criteria used by the Stockholm Convention on persistent organic pollutants under the United Nations Environment Programme are not always able to identify the actual bioaccumulative capacity of some substances, by use of chemical properties such as the octanol-water partitioning coefficient. Trophic magnification factors (TMFs) were suggested as a more reliable tool for bioaccumulation assessment of chemicals that have been in commerce long enough to be quantitatively measured in environmental samples. TMFs are increasingly used to quantify biomagnification and represent the average diet-to-consumer transfer of a chemical through food webs. They differ from biomagnification factors, which apply to individual species and can be highly variable between predator-prey combinations. The TMF is calculated from the slope of a regression between the chemical concentration and trophic level of organisms in the food web. The trophic level can be determined from stable N isotope ratios (δ(15) N). In this article, we give the background for the development of TMFs, identify and discuss impacts of ecosystem and ecological variables on their values, and discuss challenges and uncertainties associated with contaminant measurements and the use of δ(15) N for trophic level estimations. Recommendations are provided for experimental design, data treatment, and statistical analyses, including advice for users on reporting and interpreting TMF data. Interspecies intrinsic ecological and organismal properties such as thermoregulation, reproductive status, migration, and age, particularly among species at higher trophic levels with high contaminant concentrations, can influence the TMF (i.e., regression slope). Following recommendations herein for study design, empirical TMFs are likely to be useful for understanding the food web biomagnification potential of chemicals, where the target is to definitively identify if chemicals biomagnify (i.e., TMF > or < 1). TMFs may be less useful in species- and site-specific risk assessments, where the goal is to predict absolute contaminant concentrations in organisms in relation to threshold levels.