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Acute vs. chronic EEG effects in maprotiline- and in clomipramine-treated depressive inpatients and the prediction of therapeutic outcome
November 1994
November 1994
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Abstract
Patients treated with the norepinephrine uptake inhibitor maprotiline showed an opposite
tendency between acute and chronic effect of EEG. Whereas the acute effect indicated
a decrease upon EEG vigilance, the chronic effect indicated an increase. Under clomipramine
which acts upon different transmitter systems in a complex, up to now not fully understood
way, acute and chronic EEG effects could not be differentiated.