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      Metalloproteinases and their inhibitors in matrix remodeling

      Trends in Genetics

      Elsevier BV

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          Abstract

          The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions. Interestingly, experiments designed to improve our understanding of metalloproteinase regulation have also resulted in new insights into mechanisms by which growth factors and proto-oncogenes may regulate biological processes.

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          Author and article information

          Journal
          Trends in Genetics
          Trends in Genetics
          Elsevier BV
          01689525
          1990
          1990
          : 6
          : 121-125
          Article
          2132731
          © 1990

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