Recent studies have been considered to symbiotic interactions of the human gastrointestinal
microbiota and human lifestyle-related disorders. The human gastrointestinal microbiota
continuously stimulates the immune system against opportunistic and pathogen bacteria
from infancy. Changes in gastrointestinal microbiota have been associated with numbers
of human diseases such as allergic diseases, autoimmune encephalitis, atherosclerosis,
colorectal cancer, obesity, diabetes etc. In this review article, we evaluate studies
on the roles of human gastrointestinal microbiota and interference pathogenicity in
allergic diseases, obesity, and diabetes. Several studies indicated association between
allergic diseases and changes in bacterial balance such as increased of Clostridium
spp., some species of Bifidobacterium spp., or decreased of Bacteroidetes phylum and
some species of Bifiobacterium spp. and production of specific short-chain fatty acids
due to food type, delivery modes of infant, infant evolvement environment and time
of getting bacteria at an early-life age. In addition, obesity and diabetes are associated
with food type, production of short chain fatty acids undergo fermentation of the
intestinal microbiota, metabolic endotoxemia, endocannabinoid system and properties
of the immune system. Well-characterized underlying mechanisms may provide novel strategies
for using prebiotic and probiotic to prevent and treatment of allergic diseases, obesity,
diabetes, and other lifestyle-related disorders.