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      The Golgi complex: In vitro veritas?

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      Cell
      Cell Press

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          Assembly of asparagine-linked oligosaccharides.

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            Intracellular aspects of the process of protein synthesis.

            G E Palade (1975)
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              Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments.

              A set of 11 clones encoding putative GTP binding proteins highly homologous to the yeast YPT1/SEC4 gene products have been isolated from an MDCK cell cDNA library. We localized three of the corresponding proteins in mammalian cells by using affinity-purified antibodies in immunofluorescence and immunoelectron microscopy studies. One, the MDCK homolog of rab2, is associated with a structure having the characteristics of an intermediate compartment between the endoplasmic reticulum and the Golgi apparatus. The second, rab5, is located at the cytoplasmic surface of the plasma membrane and on early endosomes, while the third, rab7, is found on late endosomes. These findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells.
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                Author and article information

                Journal
                Cell
                Cell
                Cell
                Cell Press
                0092-8674
                1097-4172
                14 April 2004
                6 March 1992
                14 April 2004
                : 68
                : 5
                : 829-840
                Affiliations
                [a ]Department of Cell Biology Yale University School of Medicine New Haven, Connecticut 06510 USA
                [b ]Cell Biology Program European Molecular Biology Laboratory 1 Meyerhofstrasse D-6900 Heidelberg, Federal Republic of Germany
                Article
                0092-8674(92)90027-A
                10.1016/0092-8674(92)90027-A
                7133332
                1547485
                2c5d506d-f4fa-4839-a238-c0f21f6d20c7
                Copyright © 1992 .

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                Cell biology
                Cell biology

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