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      TINU Syndrome Associated with Reduced Complement Levels

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          The TINU syndrome (tubulointerstitial nephritis and uveitis) was first described by Dobrin et al. in 1975. Since then, more than 50 cases have been documented each with diverse immunopathogenetic and genetic characteristics. The aim of this report is to describe a case of TINU associated with reduced complement levels. We profile a 48-year-old white female with persistently reduced C4 complement levels during the acute phase of the pathology and with an unaltered immunologic profile. Renal biopsy evidenced a significant lymphocytic interstitial infiltration. Immunohistochemical studies of the interstitium infiltrates was positive for the presence of the T (CD3) markers (CD4 > CD8). Steroid therapy yielded a complete regression of the symptomatology with normalization of the complement levels. We suggest that it is possible to hypothesize that the various immunologic alterations associated with TINU, including the transient reduction complement levels, may be secondary to multiple inflammatory mechanisms which express themselves throughout the pathology.

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          Abnormal Distribution of Mesangium-Specific Laminin in Glomeruli of Patients with Idiopathic Membranous Nephropathy

          Using a monoclonal antibody, the distribution of the mesangium-specific laminin that binds only to the mesangium in normal kidney, was studied immunohistochemically in renal tissues obtained from patients with different glomerulonephritides including idiopathic membranous nephropathy. In minimal change nephrotic syndrome and IgA nephropathy, the mesangium-specific laminin staining was restricted to the mesangium, as is observed in the normal kidney. However, in patients with idiopathic membranous nephropathy, the monoclonal antibody against the mesangium-specific laminin reacted with the glomerular peripheral capillary walls including subepithelial protrusions or ‘spikes’, as well as with the mesangium. These results suggest that the quality of laminin produced in response to the challenge of immune deposits in the peripheral capillary walls may be different from that in the rest of the glomerular basement membrane in idiopathic membranous nephropathy.

            Author and article information

            S. Karger AG
            10 October 2001
            : 89
            : 3
            : 340-341
            aDepartment of Nephrology and Dialysis, Monselice Hospital, Monselice; bDepartment of Nephrology and Dialysis, S. Bortolo Hospital, Vicenza, and cInstitute of Pathology, S. Bortolo Hospital, Vicenza, Italy
            46096 Nephron 2001;89:340–341
            © 2001 S. Karger AG, Basel

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            Page count
            Figures: 1, References: 7, Pages: 2
            Self URI (application/pdf):
            Case Report

            Cardiovascular Medicine, Nephrology

            TINU syndrome, Iridocyclitis, Complement levels


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