Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair.

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Abstract

Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This "lineage infidelity" recreates a state akin to transient wound repair that persists to maintain uncontrolled growth.

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Journal

Journal ID (iso-abbrev): Cell

Title: Cell

Publisher: Elsevier BV

ISSN (Electronic): 1097-4172

ISSN (Print): 0092-8674

Publication date (Electronic): May 04 2017

Volume: 169

Issue: 4

Affiliations

[1 ] Stem Cell Program, Divisions of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

[2 ] Stem Cell Program, Divisions of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: carla.kim@childrens.harvard.edu.

Article

Publisher Item ID: S0092-8674(17)30484-1

DOI: 10.1016/j.cell.2017.04.030

PubMed ID: 28475887

SO-VID: 2c88c03a-0429-4af4-964e-364611e87e27

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