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Inhibition of Sonic Hedgehog Signaling Pathway by Thiazole Antibiotic Thiostrepton Attenuates the CD44+/CD24-Stem-Like Population and Sphere-Forming Capacity in Triple-Negative Breast Cancer.
Na Yang ,
Tai-Cheng Zhou ,
Xiu-xia Lei ,
Chang Wang ,
Min Yan ,
Zi-Feng Wang ,
Wei Liu ,
Jian Wang ,
Kai-Hua Ming ,
Bi-Cheng Wang ,
Bang-Lao Xu ,
Quentin Liu
2016
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Abstract
Triple-negative breast cancer (TNBC) represents a particular clinical challenge because these cancers do not respond to endocrine therapy or other available targeted agents. The lack of effective agents and obvious targets are major challenges in treating TNBC. In this study we explored the cytostatic effect of thiazole ring containing antibiotic drug thiostrepton on TNBC cell lines and investigated the molecular mechanism.