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      Analysis of Blood Spot 17α-Hydroxyprogesterone Concentration in Neonates

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          Blood spot 17α-hydroxyprogesterone (17-OHP) concentrations were measured in 515 infants aged from the 4th to the 81 st day of life, using a fluorescence enzyme immunoassay method, and the values obtained were analyzed with respect to birth weight, gestational age at birth and sampling age, to obtain accurate reference ranges and to decide appropriate cut-off limits in a neonatal mass screening for steroid 21 -hydroxylase deficiency. The results obtained indicate that the blood spot 17-OHP values in neonates should be interpreted using several different reference ranges obtained on the basis of the equivalent age of gestation at blood sampling. In the mass screening, therefore, the cut-off limits for recall are decided by these reference ranges as follows: (1) for blood resampling, 120, 30 and 25 nmol/l for the equivalent sampling ages of 31 weeks or less, 32–41 weeks and 42 weeks or more, respectively, and (2) for rapid confirmation of the disease by means of physical and laboratory examinations, 210, 60 and 60 nmol/l, respectively.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 30
          : 6
          : 246-251
          aDepartment of Pediatrics, Faculty of Medicine, Tokyo Medical and Dental University; bTokyo Branch of the Association of Health Service; cTokyo Branch of the Japan Association for Maternal Welfare; dDepartment of Pediatrics, Second Hospital, Tokyo Women’s Medical College; eDepartment of Pediatrics, Tokyo Metropolitan Kiyose Children’s Hospital; fDepartment of Pediatrics, School of Medicine, Nihon University, Tokyo, Japan
          181071 Horm Res 1988;30:246–251
          © 1988 S. Karger AG, Basel

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          Pages: 6
          Original Paper


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