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      Improved Sodium and PAH Transport in the Isolated Fluorocarbon-Perfused Rat Kidney

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          Abstract

          The effect of an artificial O<sub>2</sub> carrier (emulsion of the perfluorochemical FC43® with Pluronic-F-108®) on the functional capability of the isolated perfused rat kidney was tested. In control series hydroxyethyl starch (HES) instead of fluorocarbon was used. Improving O<sub>2</sub> supply in FC 43 experiments raised Na reabsorption to 149 µmol/g × min compared to 84.1 µmol/g × min in HES experiments. In the presence of PAH, however, Na reabsorption in FC 43 experiments was only 115 µmol/g × min. In both series, perfusion flow, calculated on the basis of Cpah, remained below the directly measured flow rate, unless analysis included all metabolites of PAH. 7V-acetylated metabolites of PAH were released at a 5 times higher rate by kidneys perfused with FC 43 than by HES-perfused organs. These results demonstrate that sufficient O<sub>2</sub> supply is critical both for reabsorption of Na+ and for handling of PAH. Increased tubular Na reabsorption in the absence of PAH indicates that even during perfusion with FC 43 O<sub>2</sub> supply is marginal.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1978
          1978
          02 December 2008
          : 22
          : 4-6
          : 423-431
          Affiliations
          Lehrstuhl II, Physiologisches Institut der Universität Kiel, Kiel
          Article
          181485 Nephron 1978;22:423–431
          10.1159/000181485
          84346
          2c8de5ff-a6f1-4de1-9e51-32a56d6eb690
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 31 January 1977
          : 28 January 1978
          Page count
          Pages: 9
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          Artificial O2 carrier,Rat kidney,Metabolization of PAH,Na reabsorption,Perfluorochemicals,Clearance of PAH,Isolated perfusion

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