Fabrication of Electrospun Chitosan and Chitosan/Poly(ethylene oxide) Nanofiber Webs and Assessment of Their Antimicrobial Activity

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Abstract

In recent years, production of nano-sized wound dressing materials from biopolymers by electrospinning method has attracted great attention. In this study, chitosan that is an inherently antimicrobial polymer and chitosan (CS)/poly(ethylene oxide) (PEO) blend solutions were electrospun to obtain nanofiber webs for wound-dressing applications. Although electrospinning of chitosan with PEO was previously studied, this study emphasized the effect of molecular weight of polymer used, total polymer concentration and electrical conductivity of polymer solution on fiber formation. Results show that selection of suitable solvent and determination of optimum process parameters were key factors for obtaining uniform nanofibers. Antimicrobial activities of these nanofiber webs against S.aureus, E.coli, and C.albicans were tested according to AATCC 100–2004. Over 99% reduction in the number of microorganisms with pure chitosan nanofibers and over 50% reduction with CS/PEO blend nanofibers were obtained.

Most cited references 29

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Antimicrobial properties of chitosan and mode of action: a state of the art review.

Ming Kong, Xi Chen, Ke Xing … (2010)

Owing to its high biodegradability, and nontoxicity and antimicrobial properties, chitosan is widely-used as an antimicrobial agent either alone or blended with other natural polymers. To broaden chitosan's antimicrobial applicability, comprehensive knowledge of its activity is necessary. The paper reviews the current trend of investigation on antimicrobial activities of chitosan and its mode of action. Chitosan-mediated inhibition is affected by several factors can be classified into four types as intrinsic, environmental, microorganism and physical state, according to their respective roles. In this review, different physical states are comparatively discussed. Mode of antimicrobial action is discussed in parts of the active compound (chitosan) and the target (microorganisms) collectively and independently in same complex. Finally, the general antimicrobial applications of chitosan and perspectives about future studies in this field are considered. Copyright © 2010 Elsevier B.V. All rights reserved.