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      Modulation of Lordosis Behavior of Female Rats by Naloxone, β-Endorphin and Its Antiserum in the Mesencephalic Central Gray: Possible Mediation via GnRH

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          The role of endogenous opiate peptides in the mesencephalic central gray (MCG) and their possible interactions with gonadotropin-releasing hormone (GnRH) in the regulation of lordosis behavior was assessed in ovariectomized, estrogen-treated and estrogen-progesterone-treated female rats. Lordosis behavior triggered by male mounting was enhanced by microinfusion of naloxone and anti-β-endorphin-globulin (anti-β-end-G) but not by anti-met-enkephalin-glob-ulin or anti-dynorphin-globulin into the MCG in both estrogen-treated and estrogen- (low dose) progesterone-treated females. The potentiating effects of naloxone and anti-β-end-G could be blocked by a preinfusion of either anti-GnRH-globulin or an antagonist analog of GnRH directly into the MCG. However, two potent antagonist analogs of GnRH were not effective in blocking lordosis indicating a dissociation between their neural actions and their known inhibitory effects on luteinizing hormone release. Conversely, β-endorphin but not met-enkephalin or dynorphin<sub>1–17</sub> infused into the MCG inhibited lordosis behavior in both estrogen-treated and estrogen-progesterone-treated rats. This β-endorphin-induced inhibition of lordosis in the estrogen-treated rats could be overcome by GnRH microinfused directly into the MCG which potentiated lordosis to high levels. These observations provide evidence that β-endorphin may be the sole opiate peptide in the MCG involved in the control of lordosis behavior and also suggests a functional relationship with GnRH systems in the MCG in such a regulatory mechanism.

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          Author and article information

          S. Karger AG
          28 March 2008
          : 39
          : 3
          : 222-230
          Neuroendocrine Research Unit and Laboratory for Behavioural Neurobiology, Animal Physiology Division, Agricultural Research Council, Meat Research Institute, Langford, Bristol, UK
          123983 Neuroendocrinology 1984;39:222–230
          © 1984 S. Karger AG, Basel

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          Pages: 9
          Original Paper


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