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CYP2C9 allelic variants: ethnic distribution and functional significance
November 2002
November 2002
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Abstract
Cytochrome P-450 (CYP) 2C9 CYP2C9 is a polymorphically expressed enzyme responsible
for the metabolism of several clinically important drugs, some with a low therapeutic
index. This review summarizes the structure-function relationship of the CYP2C9 promoter
and coding regions, known polymorphisms, the functional significance of various CYP2C9
alleles in vitro and in vivo, and their population frequencies. In addition, possible
molecular mechanisms underlying ethnic variability in the metabolism of CYP2C9 substrate
drugs are discussed.