Genetic risk load according to the site of intracranial aneurysms.

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Abstract

We investigated whether risk alleles of single nucleotide polymorphisms associated with intracranial aneurysm (IA) are enriched in patients with familial IA, IA located at the middle cerebral artery (MCA), or IA rupture at a younger age.

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Journal

Journal ID (iso-abbrev): Neurology

Title: Neurology

ISSN (Electronic): 1526-632X

ISSN (Print): 0028-3878

Publication date (Electronic): Jul 1 2014

Volume: 83

Issue: 1

Affiliations

[1 ] From the Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience (F.N.G.v.t.H., R. Kleinloog, G.J.E.R., Y.M.R.), and Departments of Epidemiology (P.I.W.d.B.) and Medical Genetics (P.I.W.d.B.), University Medical Center Utrecht, the Netherlands; Neurosurgery of NeuroCenter (M.I.K., M.v.u.z.F., J.E.J.), Kuopio University Hospital; Public Health Genomics Unit (E.I.G., A.L.), Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki; Institute for Molecular Medicine Finland (E.I.G.), University of Helsinki; Department of Neurosurgery (E.I.G., H.L., R. Kivisaari, M.N., J.H.), Helsinki University Central Hospital, Finland; and Department of Neurology (M.C.B., D.v.d.B.), Center of Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, the Netherlands. f.vanthof@umcutrecht.nl.

[2 ] From the Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience (F.N.G.v.t.H., R. Kleinloog, G.J.E.R., Y.M.R.), and Departments of Epidemiology (P.I.W.d.B.) and Medical Genetics (P.I.W.d.B.), University Medical Center Utrecht, the Netherlands; Neurosurgery of NeuroCenter (M.I.K., M.v.u.z.F., J.E.J.), Kuopio University Hospital; Public Health Genomics Unit (E.I.G., A.L.), Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki; Institute for Molecular Medicine Finland (E.I.G.), University of Helsinki; Department of Neurosurgery (E.I.G., H.L., R. Kivisaari, M.N., J.H.), Helsinki University Central Hospital, Finland; and Department of Neurology (M.C.B., D.v.d.B.), Center of Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, the Netherlands.

Article

Publisher Item ID: WNL.0000000000000547

DOI: 10.1212/WNL.0000000000000547

PubMed ID: 24879094

SO-VID: 2cd9843e-4bbd-4f14-972c-5e681498e344

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