0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Intestinal absorption of cholecalciferol and 25-hydroxycholecalciferol in chronic cholestatic liver disease.

      The American Journal of Clinical Nutrition
      Adult, Calcifediol, metabolism, Cholangitis, Cholecalciferol, Chronic Disease, Female, Humans, Intestinal Absorption, Liver Cirrhosis, Biliary, Male, Middle Aged, Sclerosis

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          We compared the absorption of cholecalciferol and 25-hydroxycholecalciferol in normal subjects and in patients with mild and severe cholestatic liver disease. 3H-cholecalciferol and 3H-25-hydroxycholecalciferol were given orally and serial blood samples were drawn for measurement of the serum level of radiolabeled vitamin. Absorption of 25-hydroxycholecalciferol peaked earlier and was greater than absorption of cholecalciferol at all times in all three groups. Patients with mild cholestasis (normal bilirubin and fecal fat excretion) absorbed both forms of the vitamin normally. Those with severe cholestasis (jaundice and steatorrhea) had minimal absorption of cholecalciferol but relatively preserved absorption of 25-hydroxycholecalciferol. Absorption of cholecalciferol and 25-hydroxycholecalciferol was inversely related to fecal fat excretion. The superior absorption of 25-hydroxycholecalciferol may partly explain its greater efficacy in oral treatment of vitamin D deficiency in patients with severe cholestasis.

          Related collections

          Author and article information

          Journal
          2825501
          10.1093/ajcn/46.6.1011

          Chemistry
          Adult,Calcifediol,metabolism,Cholangitis,Cholecalciferol,Chronic Disease,Female,Humans,Intestinal Absorption,Liver Cirrhosis, Biliary,Male,Middle Aged,Sclerosis

          Comments

          Comment on this article