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      Processing and Characterization of SrTiO₃-TiO₂ Nanoparticle-Nanotube Heterostructures on Titanium for Biomedical Applications.

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          Abstract

          Surface properties such as physicochemical characteristics and topographical parameters of biomaterials, essentially determining the interaction between the biological cells and the biomaterial, are important considerations in the design of implant materials. In this study, a layer of SrTiO3-TiO2 nanoparticle-nanotube heterostructures on titanium has been fabricated via anodization combined with a hydrothermal process. Titanium was anodized to create a layer of titania (TiO2) nanotubes (TNTs), which was then decorated with a layer of SrTiO3 nanoparticles via hydrothermal processing. SrTiO3-TiO2 heterostructures with high and low volume fraction of SrTiO3 nanoparticle (denoted by 6.3-Sr/TNTs and 1.4-Sr/TNTs) were achieved by using a hydrothermal processing time of 12 and 3 h, respectively. The in vitro biocompatibility of the SrTiO3-TiO2 heterostructures was assessed by using osteoblast cells (SaOS2). Our results indicated that the SrTiO3-TiO2 heterostructures with different volume fractions of SrTiO3 nanoparticles exhibited different Sr ion release in cell culture media and different surface energies. An appropriate volume fraction of SrTiO3 in the heterostructures stimulated the secretion of cell filopodia, leading to enhanced biocompatibility in terms of cell attachment, anchoring, and proliferation on the heterostructure surface.

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          Author and article information

          Journal
          ACS Appl Mater Interfaces
          ACS applied materials & interfaces
          American Chemical Society (ACS)
          1944-8252
          1944-8244
          Jul 29 2015
          : 7
          : 29
          Affiliations
          [1 ] †Institute for Frontier Materials, Deakin University, Geelong, Victoria 3217, Australia.
          [2 ] ‡School of Aerospace, Mechanical and Manufacturing Engineering, RMIT University, Melbourne, Victoria 3000, Australia.
          Article
          10.1021/acsami.5b04304
          26136139
          2ce6872d-aef9-446f-94ea-9154aedd72dd
          History

          SaOS2 cell,SrTiO3−TiO2 nanoparticle−nanotube heterostructure,TiO2 nanotube,biocompatibility,surface energy

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