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      Determination of Immunoreactive Trypsin, Pancreatic Elastase and Chymotrypsin in Extracts of Human Feces and Ileostomy Drainage

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          The total daily amount of extractable cationic trypsin, chymotrypsin, and pancreatic elastase 2 in feces and ileostomy fluids has been studied in normal individuals and healthy colectomized subjects. Quantitation was performed using immunological assays with polyethylene glycol as a fecal marker. The extractable amount of each of these enzymes in the feces of normal individuals was less than 1 mg/24 h. However, in fecal extracts from antibiotic-treated normal individuals a 100-fold increase in immunoreactive cationic trypsin was observed, while chymotrypsin and elastase 2 were only 2- to 3-fold higher. In extracts from ileostomy fluids cationic trypsin, elastase, and chymotrypsin all showed mean values in the order of 50–200 mg/24 h. The characterization of the immunoreactivity of pancreatic proteases showed no qualitative differences when measured in duodenal juice or fecal and ileostomy extracts.

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          Author and article information

          S. Karger AG
          28 January 2009
          : 27
          : 1
          : 8-15
          Departments of Surgery, Clinical Chemistry and Experimental Research, Malmö General Hospital, University of Lund, Malmö, Sweden
          198913 Digestion 1983;27:8–15
          © 1983 S. Karger AG, Basel

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          Pages: 8
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