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      Hyperlipidemia, Blood Lipid Level, and the Risk of Glaucoma: A Meta-Analysis

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      Investigative Opthalmology & Visual Science

      Association for Research in Vision and Ophthalmology (ARVO)

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          Most cited references 47

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          Myopia as a risk factor for open-angle glaucoma: a systematic review and meta-analysis.

          To determine the association between myopia and open-angle glaucoma. Systematic review and meta-analysis of observational studies. Thirteen studies involving 48 161 individuals. Articles published between 1994 and 2010 were identified in PubMed, Embase, and reference lists. Study-specific odds ratios (ORs) were pooled using a random effects model. Odds ratios with 95% confidence intervals (CIs) of myopia as a risk factor for open-angle glaucoma. Data from 11 population-based cross-sectional studies were included in the main analyses. The pooled OR of the association between myopia and glaucoma based on 11 risk estimates was 1.92 (95% CI, 1.54-2.38). On the basis of 7 risk estimates, the pooled ORs of the associations between low myopia (myopia up to -3 D) and glaucoma and between high myopia (≤-3 D myopic) and glaucoma were 1.65 (1.26-2.17) and 2.46 (1.93-3.15), respectively. There was considerable heterogeneity among studies that reported an association between any myopia and glaucoma (I(2)=53%) and low myopia and glaucoma (I(2)=29%), but not for high myopia and glaucoma (I(2)=0%). After omitting studies that contributed significantly to the heterogeneity, the pooled ORs were 1.88 (1.60-2.20) for any myopia and glaucoma and 1.77 (1.41-2.23) for low myopia and glaucoma. Individuals with myopia have an increased risk of developing open-angle glaucoma. The author(s) have no proprietary or commercial interest in any materials discussed in this article. Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
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            Retinal vascular tortuosity, blood pressure, and cardiovascular risk factors.

            To examine the relationship of retinal vascular tortuosity to age, blood pressure, and other cardiovascular risk factors. Population-based, cross-sectional study. A total of 3280 participants aged 40 to 80 years from the Singapore Malay Eye Study (78.7% response rate). Retinal arteriolar and venular (vascular) tortuosity were quantitatively measured from fundus images using a computer-assisted program. Retinal vascular tortuosity was defined as the integral of the curvature square along the path of the vessel, normalized by the total path length. Data on blood pressure and major cardiovascular disease (CVD) risk factors were collected from all participants. Retinal arteriolar and venular tortuosity. A total of 2915 participants contributed data to this study. The mean (standard deviation) and median were 2.99 (1.40) and 2.73 for retinal arteriolar tortuosity (×10(4)), and 4.64 (2.39) and 4.19 for retinal venular tortuosity (×10(4)), respectively. Retinal venules were significantly more tortuous than retinal arterioles (P<0.001). In multivariable-adjusted linear regression models, less arteriolar tortuosity was independently associated with older age, higher blood pressure, higher body mass index (BMI), and narrower retinal arteriolar caliber (all P<0.05); greater venular tortuosity was independently associated with younger age, higher blood pressure, lower high-density lipoprotein (HDL) cholesterol level, and wider retinal venular caliber (all P<0.05). Retinal arteriolar tortuosity was associated with older age and higher levels of blood pressure and BMI, whereas venular tortuosity was also associated with lower HDL level. The quantitative assessment of retinal vascular tortuosity from retinal images may provide further information regarding effects of cardiovascular risk factors on the retinal vasculature. Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
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              Structure of the Human Lipid Exporter ABCA1

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                Author and article information

                Journal
                Investigative Opthalmology & Visual Science
                Invest. Ophthalmol. Vis. Sci.
                Association for Research in Vision and Ophthalmology (ARVO)
                1552-5783
                March 01 2019
                March 21 2019
                : 60
                : 4
                : 1028
                Affiliations
                [1 ]Aier Eye Hospital Group, Ningbo Aier Guangming Eye Hospital, Ningbo, China
                [2 ]Aier Eye Hospital Group, Wuhan Aier Eye Hospital, Wuhan, China
                Article
                10.1167/iovs.18-25845
                © 2019

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