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      Host association of Borrelia burgdorferi sensu lato – the key role of host complement

      , , , , , ,
      Trends in Microbiology
      Elsevier BV

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          Abstract

          Borrelia burgdorferi sensu lato (s.l.), the tick-borne agent of Lyme borreliosis, is a bacterial species complex comprising 11 genospecies. Here, we discuss whether the delineation of genospecies is ecologically relevant. We provide evidence that B. burgdorferi s.l. is structured ecologically into distinct clusters that are host specific. An immunological model for niche adaptation is proposed that suggests the operation of complement-mediated selection in the midgut of the feeding tick. We conclude that vertebrate hosts rather than tick species are the key to Lyme borreliosis spirochaete diversity.

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          Author and article information

          Journal
          Trends in Microbiology
          Trends in Microbiology
          Elsevier BV
          0966842X
          February 2002
          February 2002
          : 10
          : 2
          : 74-79
          Article
          10.1016/S0966-842X(01)02298-3
          11827808
          2cfff7dd-7693-4283-89f6-1dbf19461e40
          © 2002

          https://www.elsevier.com/tdm/userlicense/1.0/

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