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      Orientation of Nuclei as Indicators of Smooth Muscle Cell Alignment in the Cerebral Artery


      Journal of Vascular Research

      S. Karger AG

      Smooth muscle, Stereology, Light microscopy, Brain arteries

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          Geometric measurements were made of the nuclei of the muscle cells of the tunica media of human intracranial arteries. The nuclei measured 37 ± (SD) 6.4 µm in length, and 2.0 ± (SD) 0.83 µm average width and have a number density of 10<sup>5</sup> nuclei/mm<sup>3</sup> (number per unit volume of tunica media). From the work of others it was known that the nuclei are centrally located within the cytoplasm of the muscle cell; because of this we have used the nuclei as indicators of alignment of the muscle cells themselves, making measurements from light micrographs of arterial sections stained with haematoxylin and eosin. On average, the nuclei were oriented at an angle that was not significantly different from a zero-degree pitch for the five sections analyzed in detail.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 16
          : 1
          : 43-51
          Department of Biophysics, Health Sciences Centre, University of Western Ontario, London, Ont.
          158189 Blood Vessels 1979;16:43–51
          © 1979 S. Karger AG, Basel

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          Page count
          Pages: 9
          Original Paper


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