Orientation of Nuclei as Indicators of Smooth Muscle Cell Alignment in the Cerebral Artery

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Abstract

Geometric measurements were made of the nuclei of the muscle cells of the tunica media of human intracranial arteries. The nuclei measured 37 ± (SD) 6.4 µm in length, and 2.0 ± (SD) 0.83 µm average width and have a number density of 10<sup>5</sup> nuclei/mm<sup>3</sup> (number per unit volume of tunica media). From the work of others it was known that the nuclei are centrally located within the cytoplasm of the muscle cell; because of this we have used the nuclei as indicators of alignment of the muscle cells themselves, making measurements from light micrographs of arterial sections stained with haematoxylin and eosin. On average, the nuclei were oriented at an angle that was not significantly different from a zero-degree pitch for the five sections analyzed in detail.

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Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1979

Publication date (Print): 1979

Publication date (Electronic): 19 September 2008

Volume: 16

Issue: 1

Pages: 43-51

Affiliations

Department of Biophysics, Health Sciences Centre, University of Western Ontario, London, Ont.

Article

Publisher ID: 158189 Other ID: Blood Vessels 1979;16:43–51

DOI: 10.1159/000158189

SO-VID: 2d0050b8-0cc3-4820-b42c-6380a5c48665

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 08 November 1977

Date accepted : 30 January 1978

Page count

Pages: 9

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