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      Oxidative stress and redox regulation of gametogenesis, fertilization, and embryonic development

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          Abstract

          Oxidative stress caused by elevated reactive oxygen species (ROS) is one of the predominant causes of both male and female infertility. Oxidative stress conditions cause either cell death or senescence by oxidation of cellular molecules including nucleic acid, proteins, and lipids. It is particularly important to minimize oxidative stress when in vitro fertilization is performed for the purpose of assisted reproduction. The problems associated with assisted reproductive technology are becoming evident, and it is now the time to clarify its mechanisms and cope with them. On the other hand, the beneficial roles of ROS, such as intracellular signaling, have become evident. The antithetical functions of ROS make it more difficult to overcome the problems caused by oxidative stress. Despite the difficulty in understanding mammalian reproduction, the mechanisms and problems can be gradually unveiled by advanced technology such as genetic modification of animals.

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          Author and article information

          Contributors
          s-tsunoda@med.id.yamagata-u.ac.jp
          Journal
          Reprod Med Biol
          Reprod. Med. Biol
          10.1111/(ISSN)1447-0578
          RMB2
          Reproductive Medicine and Biology
          John Wiley and Sons Inc. (Hoboken )
          1445-5781
          1447-0578
          27 September 2013
          April 2014
          : 13
          : 2 ( doiID: 10.1111/rmb2.2014.13.issue-2 )
          : 71-79
          Affiliations
          [ 1 ] Department of Biochemistry and Molecular Biology, Graduate School of Medical Science Yamagata University 2‐2‐2 Iidanishi 990‐9585 Yamagata Japan
          [ 2 ] Laboratory of Animal Reproduction, Graduate School of Agricultural Sciences Yamagata University Yamagata Japan
          Author notes
          [*] [* ] +81‐23‐6285229

          +81‐23‐6285230

          s-tsunoda@ 123456med.id.yamagata-u.ac.jp

          Article
          PMC5904624 PMC5904624 5904624 RMB20170
          10.1007/s12522-013-0170-0
          5904624
          29699151
          2d0c8a11-24c0-474d-b704-dd8a95012b64
          © The Japan Society for Reproductive Medicine
          History
          : 08 June 2013
          : 18 September 2013
          Page count
          Figures: 4, Tables: 0, References: 97, Pages: 9, Words: 7170
          Categories
          Review Article
          Review Article
          Custom metadata
          2.0
          rmb20170
          April 2014
          Converter:WILEY_ML3GV2_TO_NLMPMC version:version=5.3.4 mode:remove_FC converted:18.04.2018

          Spermatogenesis,ROS signaling,Oxidative stress,Oogenesis,In vitro fertilization

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