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      Crystallins of Lens Epithelial Cells during Aging and Differentiation

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      Ophthalmic Research

      S. Karger AG

      Rat, Lens, Cell culture, Proteins, Differentiation, Aging

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          Abstract

          Lens epithelial cells from rats were serially subcultured. Five distinct stages (A–E) developed, which have been classified according to morphological and cellular parameters. The proteins of these cells were analyzed by isoelectric focusing. The differences in the protein patterns ( β- and γ-region) in diploid as well as in aneuploid stages are discussed. Changes in the protein patterns of diploid stage B cells with different CPD numbers are considered as age-related effects. The occurrence of elongated cell forms and the synthesis of γ-crystallin (only in the diploid stage) favours the assumption that lens epithelial cells from the rat retain some features of their differentiation capacity in vitro.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          978-3-8055-0862-9
          978-3-318-02127-1
          0030-3747
          1423-0259
          1979
          1979
          03 December 2009
          : 11
          : 5-6
          : 355-359
          Affiliations
          Institute of Radiobiology, University of Bonn, Bonn
          Article
          265033 Ophthalmic Res 1979;11:355–359
          10.1159/000265033
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Growth Control, Differentiation, and Ageing of the Eye Lens

          Vision sciences, Ophthalmology & Optometry, Pathology

          Rat, Lens, Cell culture, Proteins, Differentiation, Aging

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