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      Crystallins of Lens Epithelial Cells during Aging and Differentiation


      Ophthalmic Research

      S. Karger AG

      Rat, Lens, Cell culture, Proteins, Differentiation, Aging

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          Lens epithelial cells from rats were serially subcultured. Five distinct stages (A–E) developed, which have been classified according to morphological and cellular parameters. The proteins of these cells were analyzed by isoelectric focusing. The differences in the protein patterns ( β- and γ-region) in diploid as well as in aneuploid stages are discussed. Changes in the protein patterns of diploid stage B cells with different CPD numbers are considered as age-related effects. The occurrence of elongated cell forms and the synthesis of γ-crystallin (only in the diploid stage) favours the assumption that lens epithelial cells from the rat retain some features of their differentiation capacity in vitro.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 11
          : 5-6
          : 355-359
          Institute of Radiobiology, University of Bonn, Bonn
          265033 Ophthalmic Res 1979;11:355–359
          © 1979 S. Karger AG, Basel

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          Page count
          Pages: 5
          Growth Control, Differentiation, and Ageing of the Eye Lens

          Vision sciences, Ophthalmology & Optometry, Pathology

          Rat, Lens, Cell culture, Proteins, Differentiation, Aging


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