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      PEO- b-PPO star-shaped polymers enhance the structural stability of electrostatically coupled liposome/polyelectrolyte complexes

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          Abstract

          We propose a strategy to counteract the salt-driven disassembly of multiliposomal complexes made by electrostatic co-assembly of anionic small unilamellar liposomes and cationic star-shaped polyelectrolytes (made of quaternized poly(dimethylaminoethyl methacrylate) ( qPDMAEMA 100) 3.1). The combined action of ( qPDMAEMA 100) 3.1 and a nonionic star-shaped polymer (PEO 12- b-PPO 45) 4, which comprises diblock copolymer arms uniting a poly(ethylene oxide) PEO inner block and a poly(propylene oxide) PPO terminal block, leads to a stabilization of these complexes against disintegration in saline solutions. Hereby, the anchoring of the PPO terminal blocks to the lipid bilayer and the bridging between several liposomes are at the origin of the promoted structural stability. Two-focus fluorescence correlation spectroscopy verifies the formation of multiliposomal complexes with (PEO 12- b-PPO 45) 4. The polyelectrolyte and the amphiphilic polymer work synergistically, as the joint action still assures some membrane integrity, which is not seen for the mere (PEO 12- b-PPO 45) 4—liposome interaction alone.

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          Most cited references 49

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          Nanocarriers as an emerging platform for cancer therapy.

          Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Advances in protein engineering and materials science have contributed to novel nanoscale targeting approaches that may bring new hope to cancer patients. Several therapeutic nanocarriers have been approved for clinical use. However, to date, there are only a few clinically approved nanocarriers that incorporate molecules to selectively bind and target cancer cells. This review examines some of the approved formulations and discusses the challenges in translating basic research to the clinic. We detail the arsenal of nanocarriers and molecules available for selective tumour targeting, and emphasize the challenges in cancer treatment.
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            Recent advances with liposomes as pharmaceutical carriers.

            Liposomes - microscopic phospholipid bubbles with a bilayered membrane structure - have received a lot of attention during the past 30 years as pharmaceutical carriers of great potential. More recently, many new developments have been seen in the area of liposomal drugs - from clinically approved products to new experimental applications, with gene delivery and cancer therapy still being the principal areas of interest. For further successful development of this field, promising trends must be identified and exploited, albeit with a clear understanding of the limitations of these approaches.
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              Liposomal drug delivery systems: from concept to clinical applications.

               P Cullis,  T Allen (2012)
              The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and soon were proposed as drug delivery systems. The pioneering work of countless liposome researchers over almost 5 decades led to the development of important technical advances such as remote drug loading, extrusion for homogeneous size, long-circulating (PEGylated) liposomes, triggered release liposomes, liposomes containing nucleic acid polymers, ligand-targeted liposomes and liposomes containing combinations of drugs. These advances have led to numerous clinical trials in such diverse areas as the delivery of anti-cancer, anti-fungal and antibiotic drugs, the delivery of gene medicines, and the delivery of anesthetics and anti-inflammatory drugs. A number of liposomes (lipidic nanoparticles) are on the market, and many more are in the pipeline. Lipidic nanoparticles are the first nanomedicine delivery system to make the transition from concept to clinical application, and they are now an established technology platform with considerable clinical acceptance. We can look forward to many more clinical products in the future. Copyright © 2012 Elsevier B.V. All rights reserved.
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                Author and article information

                Contributors
                Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: Writing – original draft
                Role: Investigation
                Role: MethodologyRole: Resources
                Role: Formal analysisRole: Investigation
                Role: Investigation
                Role: MethodologyRole: Writing – review & editing
                Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
                Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: Writing – review & editing
                Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: Writing – review & editing
                Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                17 January 2019
                2019
                : 14
                : 1
                Affiliations
                [1 ] Institute of Physical Chemistry, RWTH Aachen University, Aachen, Germany
                [2 ] Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
                [3 ] Institute of Physical Chemistry, TU Bergakademie Freiberg, Freiberg, Germany
                University of Hyderabad, INDIA
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Article
                PONE-D-18-29642
                10.1371/journal.pone.0210898
                6336312
                30653618
                © 2019 Pinguet et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                Page count
                Figures: 9, Tables: 0, Pages: 15
                Product
                Funding
                Funded by: funder-id http://dx.doi.org/10.13039/501100001659, Deutsche Forschungsgemeinschaft;
                Award ID: RI 560/22-1
                Award Recipient :
                Funded by: funder-id http://dx.doi.org/10.13039/501100006769, Russian Science Foundation;
                Award ID: 19-43-04104
                Award Recipient :
                The work of C.P., W.R. (project RI 560/22-1) and F.P. was funded by the German Research Foundation (DFG; www.dfg.de). The work of A.S. and A.Y. (project 19-43-04104) was funded by the Russian Science Foundation (RSF; http://rscf.ru/en/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Biology and Life Sciences
                Cell Biology
                Cellular Structures and Organelles
                Vesicles
                Liposomes
                Physical Sciences
                Chemistry
                Polymer Chemistry
                Macromolecules
                Polymers
                Physical Sciences
                Materials Science
                Materials
                Polymers
                Physical Sciences
                Chemistry
                Polymer Chemistry
                Polymers
                Biology and Life Sciences
                Biochemistry
                Lipids
                Research and Analysis Methods
                Spectrum Analysis Techniques
                Fluorescence Spectroscopy
                Physical Sciences
                Physics
                Classical Mechanics
                Continuum Mechanics
                Fluid Mechanics
                Fluid Dynamics
                Hydrodynamics
                Physical Sciences
                Physics
                Electricity
                Electrostatics
                Physical Sciences
                Chemistry
                Chemical Compounds
                Salts
                Sodium Chloride
                Physical Sciences
                Physics
                Electromagnetic Radiation
                Luminescence
                Fluorescence
                Custom metadata
                All relevant data are within the manuscript and its Supporting Information files.

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