- Record: found
- Abstract: not found
- Article: not found
Homocysteine and coronary atherosclerosis
March 1996
March 1996
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Homocysteine is increasingly recognized as a risk factor for coronary artery disease.
An understanding of its metabolism and of the importance of vitamins B6 and B12 and
folate as well as enzyme levels in its regulation will aid the development of therapeutic
strategies that, by lowering circulating concentrations, may also lower risk. Possible
mechanisms by which elevated homocysteine levels lead to the development and progression
of vascular disease include effects on platelets, clotting factors and endothelium.
This review presents the clinical and basic scientific evidence supporting the risk
and mechanisms of vascular disease associated with elevated homocysteine concentrations
as well as the results of preliminary therapeutic trials.