Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Influence of Age on Vascular Adrenergic Responsiveness

      Journal of Vascular Research

      S. Karger AG

      Aging, Adrenergic responsiveness, Blood vessels, Fischer 344 rat

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The adrenergic neuroeffector mechanism of blood vessels in Fischer 344 rats was studied from young adulthood to senescence. Norepinephrine (NE) content is maintained through senescence in all veins studied as well as in the superior mesenteric artery. In contrast, NE content declined at 27 months of age in all other arteries studied. Nevertheless, vascular reactivity in vitro to adrenergic nerve stimulation and to NE was well maintained. As to beta-adrenergic responsiveness, this showed a marked decline in arteries from 1 to 6 months of age, but was unchanged in the jugular vein from 3 to 27 months. Overall, then, adrenergic responsiveness of vascular smooth muscle is well maintained in aged rats. However, this study focuses on a discrete aspect of blood pressure control in a species where atherosclerosis is not prominent. Alterations at other sites could be responsible for changes in the overall function of adrenergic cardiovascular control.

          Related collections

          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          978-3-8055-4604-1
          978-3-318-02026-7
          1018-1172
          1423-0135
          1987
          1987
          23 September 2008
          : 24
          : 3
          : 113-116
          Affiliations
          Department of Pharmacology, College of Medicine, University of California Irvine, Irvine, Calif., USA
          Article
          158681 Blood Vessels 1987;24:113–116
          10.1159/000158681
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Neurohumoral Control of Blood Vessel Tone

          Comments

          Comment on this article