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      An Evaluation of the Effects of Isosorbide 5-Mononitrate in Patients with Angina on Effort Using Dynamic Electrocardiography and Echocardiography

      a , a , a , a , b , c

      Cardiology

      S. Karger AG

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          Abstract

          We studied 14 patients, 9 males and 5 females, with an average age of 53.6 ± 9.2 years, having been suffering from effort angina for over 6 months, with positive ergometer test for angina and ST-segment depression > 1 mm. All the patients performed a washout period of 7 days at the end of which, before and after acute administration (90 min) of isosorbide 5-mononitrate or placebo some echocardiographic parameters were controlled according to a double-blind, randomized, crossover design. Moreover, after 2 months of open treatment with isosorbide 5-mononitrate (20 mg three times daily), echocardiographic parameters were investigated again. Continuous ECG monitoring (24 h) was performed after the washout period and after 2 months of treatment. After acute administration of isosorbide 5-mononitrate, we observed a reduction in pre- and afterload, whereas after 2 months of treatment the reduction in preload seems to play a more important role. Together with other mechanisms these haemodynamic changes are responsible for the substantial diminution of myocardial oxygen consumption, and consequently for the reduction of transient ischaemic episodes, both symptomatic and asymptomatic with heart rate increase. These results suggest that isosorbide 5-mononitrate exhibits a definite nitrate-typical vascular activity that is evident both after single administration and after 2 months of treatment.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-4626-3
          978-3-318-01758-8
          0008-6312
          1421-9751
          1987
          1987
          11 November 2008
          : 74
          : Suppl 1
          : 20-28
          Affiliations
          aInstitute of Clinical Medicine, bChair of Systematic Medical Therapy, University of Palermo, and cDepartment of Internal Medicine, Chair of Medical Pathology, II University of Rome, Tor Vergata, Rome, Italy
          Article
          174260 Cardiology 1987;74:20–28
          10.1159/000174260
          3300974
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Paper

          General medicine, Neurology, Cardiovascular Medicine, Internal medicine, Nephrology

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