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      Polímeros biomiméticos em química analítica. Parte 2: aplicações de MIP ("Molecularly Imprinted Polymers") no desenvolvimento de sensores químicos Translated title: Biomimetic polymers in analytical chemistry. Part 2: applications of MIP (Molecularly Imprinted Polymers) in the development of chemical sensors

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          Translated abstract

          The aim of this paper is the description of the strategies and advances in the use of MIP in the development of chemical sensors. MIP has been considered an emerging technology, which allows the synthesis of materials that can mimic some highly specific natural receptors such as antibodies and enzymes. In recent years a great number of publications have demonstrated a growth in their use as sensing phases in the construction of sensors . Thus, the MIP technology became very attractive as a promising analytical tool for the development of sensors.

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          Most cited references118

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          Synthesis of Anionic Phosphorus-Containing Heterocycles by Intramolecular Cyclizations Involving N-Functionalized Phosphinecarboxamides

          We report that the 2-phosphaethynolate anion (PCO−) reacts with propargylamines in the presence of a proton source to afford novel N-derivatized phosphinecarboxamides bearing alkyne functionalities. Deprotonation of these species gives rise to novel five- and six-membered anionic heterocycles resulting from intramolecular nucleophilic attack of the resulting phosphide at the alkyne functionality (via 5-exo-dig or 6-endo-dig cyclizations, respectively). The nature of the substituents on the phosphinecarboxamide can be used to influence the outcome of these reactions. This strategy represents a unique approach to phosphorus-containing heterocylic systems that are closely related to known organic molecules with interesting bio-active properties.
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            Protein import into mitochondria.

            Mitochondria comprise approx. 1000-3000 different proteins, almost all of which must be imported from the cytosol into the organelle. So far, six complex molecular machines, protein translocases, were identified that mediate this process. The TIM23 complex is a major translocase in the inner mitochondrial membrane. It uses two energy sources, namely membrane potential and ATP, to facilitate preprotein translocation across the inner membrane and insertion into the inner membrane. Recent research has led to the discovery of a number of new constituents of the TIM23 complex and to the unravelling of the mechanisms of preprotein translocation.
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              Electrophoresis

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Journal
                qn
                Química Nova
                Quím. Nova
                Sociedade Brasileira de Química (São Paulo )
                1678-7064
                December 2005
                : 28
                : 6
                : 1087-1101
                Affiliations
                [1 ] Universidade Estadual de Campinas Brazil
                Article
                S0100-40422005000600025
                10.1590/S0100-40422005000600025
                2d6c639a-1b7f-463c-9c2c-8b8b29bfdcdc

                http://creativecommons.org/licenses/by/4.0/

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                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-4042&lng=en
                Categories
                CHEMISTRY, MULTIDISCIPLINARY

                General chemistry
                molecularly imprinted polymers,biomimetic sensors
                General chemistry
                molecularly imprinted polymers, biomimetic sensors

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