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      Investigation of the pathogenesis of massive hemolysis in a case of Clostridium perfringens septicemia.

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          Abstract

          Massive hemolysis is a rare, usually fatal complication of Clostridium perfringens septicemia. Of all toxins produced by the bacterium, phospholipase C (PLC) is believed to be the most likely cause of hemolysis. An influence of neuraminidase has often been suspected. In the present study, a case of C. perfringens septicemia with acute massive intravascular hemolysis is described. It led to death within 4 h of admission to the hospital. While the course of events was comparable to previously reported cases, we succeeded in gaining deeper insight into the pathogenesis by monitoring serum anti-T titer and quantifying serum PLC activity during the course of the disease. We excluded an effect of neuraminidase by a negative direct antiglobulin test, a negative anti-T lectin test, and a steady serum anti-T titer of 1 in 32. Serum PLC activity, on the other hand, showed a nearly fivefold increase (6.0 to 27.3 U/l), which is consistent with the hypothesized dominant role of this enzyme.

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          Author and article information

          Journal
          Ann. Hematol.
          Annals of hematology
          0939-5555
          0939-5555
          Sep 1993
          : 67
          : 3
          Affiliations
          [1 ] Institute of Clinical Chemistry and Laboratory Medicine, Wilhelminenspital, City of Vienna, Austria.
          Article
          8373904
          2d72d24c-3050-4886-9144-cb93271ab782
          History

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