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      Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

      Proceedings of the National Academy of Sciences of the United States of America

      Antibody Formation, Antigens, CD, physiology, Antigens, CD40, Antigens, Differentiation, B-Lymphocyte, B-Lymphocytes, Cell Differentiation, Cell Division, Cells, Cultured, DNA, biosynthesis, Humans, In Vitro Techniques, Interleukin-10, pharmacology, Interleukin-4, Lymphocyte Activation, Receptors, Antigen, B-Cell, Recombinant Proteins, Viral Proteins

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          Abstract

          Interleukin 10 (IL-10), originally identified as a TH2 helper T-cell product able to inhibit cytokine production by TH1 cells, is highly homologous to BCRF1 (viral IL-10), an open reading frame in the Epstein-Barr virus genome. Here, we show that human and viral IL-10 stimulate DNA replication of B lymphocytes activated either via their antigen receptor or via their CD40 antigen. IL-4 and IL-10 display additive effects and induce a strong increase in the number of viable cells. Moreover, IL-10 induces activated B cells to secrete large amounts of IgG, IgA, and IgM, and the combination of IL-10 and IL-4 results in the secretion of the four immunoglobulin isotypes. Thus, IL-10 may play an important role in the amplification of humoral responses.

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          1371884
          48559

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