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      Oral miltefosine for Indian visceral leishmaniasis.

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          Abstract

          There are 500,000 cases per year of visceral leishmaniasis, which occurs primarily in the Indian subcontinent. Almost all untreated patients die, and all the effective agents have been parenteral. Miltefosine is an oral agent that has been shown in small numbers of patients to have a favorable therapeutic index for Indian visceral leishmaniasis. We performed a clinical trial in India comparing miltefosine with the most effective standard treatment, amphotericin B.

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          Author and article information

          Journal
          N Engl J Med
          The New England journal of medicine
          Massachusetts Medical Society
          1533-4406
          0028-4793
          Nov 28 2002
          : 347
          : 22
          Affiliations
          [1 ] Institutes of Medical Sciences, Banaras Hindu University, Varanasi, India.
          Article
          347/22/1739
          10.1056/NEJMoa021556
          12456849
          2d89a6f7-ca7c-43de-8671-b4893f2819cc
          Copyright 2002 Massachusetts Medical Society

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