Changes in Light Scattering Intensity of the Transparent Lenses of Subjects Selected from Population-Based Surveys Depending on Age: Analysis through Scheimpflug Images

Abstract

The physiological ageing changes of decreasing lens transparency were objectively evaluated in a total of 1,040 eyes selected from 1,685 individuals who were the subjects of population-based cataract epidemiological surveys performed in three climatically different survey fields in Japan. The lens transparency changes were evaluated from the light scattering intensity on thirteen different lens layers seen in slit images taken by the latest type of Scheimpflug camera. The mean percentage prevalence of cataracts in all the epidemiological survey subjects including grading from I to III, which was also judged objectively through documented images, was 64.6% in the Noto subjects, 46.6% in the Hokkaido subjects and 38.0% in the Okinawa subjects. The lens transparency at all of the measuring points decreased with ageing. The above changes, seen in the lenses of subjects in their 40s to 60s, were obviously more prominent compared with those seen in subjects in their 40s. Although there were some differences in transparency decrease with ageing among the subjects of the three areas, the authors tentatively propose to show the data obtained from the Noto subjects as representative of Japanese individuals. Lens transparency changes on each lens layer showed characteristic ageing changes and those of the representative four layers showed an exponential decrease in transparency. The decreasing ratio might accelerate from age as early as the mid-40s.