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Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study
Dolores Vilas ,
Alex Iranzo ,
Eduardo Tolosa ,
Iban Aldecoa ,
Joan Berenguer ,
Isabel Vilaseca ,
Carles Martí ,
Mónica Serradell ,
Francisco Lomeña ,
Llucia Alós ,
Carles Gaig ,
Joan Santamaria ,
Ellen Gelpi
June 2016
June 2016
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Abstract
The histological feature of Parkinson's disease is the presence of intraneuronal aggregates
of phosphorylated α-synuclein (αSyn). In patients with Parkinson's disease, deposits
of αSyn are found in the autonomic nerve fibres of the submandibular gland. Since
patients with idiopathic rapid-eye-movement sleep behaviour disorder (IRBD) can develop
Parkinson's disease and other synucleinopathies, we investigated whether αSyn deposits
could also be detected in their submandibular gland nerve fibres.