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      Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.

      Science (New York, N.Y.)
      Animals, Ascites, physiopathology, Ascitic Fluid, physiology, Capillary Permeability, Cricetinae, Guinea Pigs, Mice, Neoplasms, Experimental

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          Abstract

          Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.

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