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      Type 1 and type 2 iodothyronine deiodinases in the thyroid gland of patients with 3,5,3'-triiodothyronine-predominant Graves' disease.

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          Abstract

          3,5,3'-triiodothyronine-predominant Graves' disease (T(3)-P-GD) is characterized by a persistently high serum T(3) level and normal or even lower serum thyroxine (T(4)) level during antithyroid drug therapy. The source of this high serum T(3) level has not been clarified. Our objective was to evaluate the contribution of type 1 and type 2 iodothyronine deiodinase (D1 (or DIO1) and D2 (or DIO2) respectively) in the thyroid gland to the high serum T(3) level in T(3)-P-GD.

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          Author and article information

          Journal
          Eur. J. Endocrinol.
          European journal of endocrinology
          Bioscientifica
          1479-683X
          0804-4643
          Jan 2011
          : 164
          : 1
          Affiliations
          [1 ] Kuma Hospital, Kobe, Hyogo 650-0011, Japan.
          Article
          EJE-10-0736
          10.1530/EJE-10-0736
          20937676
          2dc8a44d-683a-4d74-a64f-beb35b11ae09

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